{"id":"W2891590598","doi":"10.1111/dom.13387","title":"Islet stress, degradation and autoimmunity","year":2018,"lang":"en","type":"review","venue":"Diabetes Obesity and Metabolism","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Nutrition, Metabolism and Diabetes","funders":"Diabetes Fonds; Juvenile Diabetes Research Foundation United States of America","keywords":"Endoplasmic-reticulum-associated protein degradation; Unfolded protein response; Endoplasmic reticulum; Proteasome; Autoimmunity; Protein degradation; Cell biology; Immune system; Biology; Ubiquitin; Inflammation; Context (archaeology); Translation (biology); Immunology; Biochemistry; Messenger RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002798417,0.0006518759,0.0006818163,0.001460723,0.0003449426,0.0009728043,0.0005031499,0.001023777,0.00289687],"category_scores_gemma":[0.0003835669,0.0001839709,0.0002788887,0.001367868,0.0004040346,0.001043486,0.0006599709,0.001394035,0.001663618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005229565,"about_ca_system_score_gemma":0.0007693443,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000675378,"about_ca_topic_score_gemma":0.0009978728,"domain_scores_codex":[0.9998775,0.00002098803,0.00001936661,0.00002199012,0.0000443297,0.00001595212],"domain_scores_gemma":[0.999893,0.00003891398,0.00001835962,0.00000511668,0.00002784597,0.00001677439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007744193,0.00007073239,0.0002240512,0.01290232,0.0000603813,0.000421215,0.0001276519,0.0003169079,0.002955837,0.008294911,0.04043202,0.9341166],"study_design_scores_gemma":[0.000006390128,0.00004833558,0.0006448374,0.001625563,0.00002782339,0.001640474,0.00005079918,0.00003692657,0.0003804641,0.002834033,0.9926951,0.000009329922],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001404641,0.9980662,0.00008702141,0.0002604792,0.0002940577,0.000002127713,0.00001025111,0.000007039044,0.001132332],"genre_scores_gemma":[0.0009799787,0.9976508,0.0001088813,0.0001705387,0.0001991253,0.000003922078,0.00001855903,0.000001516023,0.0008665958],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00289687,"threshold_uncertainty_score":0.009691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01341136575066165,"score_gpt":0.262544797419163,"score_spread":0.2491334316685013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}