{"id":"W2891611582","doi":"10.1371/journal.pgen.1007668","title":"Topoisomerases I and III inhibit R-loop formation to prevent unregulated replication in the chromosomal Ter region of Escherichia coli","year":2018,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; College of Engineering, Michigan State University; National Institutes of Health; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Genome Canada; University of Toronto; Michigan State University","keywords":"Biology; Topoisomerase; DNA gyrase; Mutant; DNA replication; Molecular biology; DNA; Topoisomerase IV; Origin of replication; SeqA protein domain; DNA supercoil; Escherichia coli; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002153825,0.0005124134,0.0003779313,0.0002208372,0.0001339356,0.0003432383,0.0002779679,0.0002371371,0.001080388],"category_scores_gemma":[0.0001985466,0.0002620199,0.0003328105,0.0001651545,0.0001676356,0.0001112716,0.0001710123,0.0005238538,0.0007443385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002275967,"about_ca_system_score_gemma":0.0002031052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005916114,"about_ca_topic_score_gemma":0.0009118471,"domain_scores_codex":[0.9996271,0.00006223119,0.00004091836,0.00006816427,0.0001335881,0.00006798192],"domain_scores_gemma":[0.9998217,0.00002747473,0.00005573513,0.00003705749,0.00002410553,0.00003394242],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000300351,0.00002139459,0.00006275537,0.00003195976,0.000004197654,0.00001257925,0.00000458063,0.00003638905,0.9989367,0.00003193588,0.00004541493,0.0007821042],"study_design_scores_gemma":[0.00001151705,0.0002171268,0.001411775,0.000005509108,0.000008783889,0.00006071302,0.000008460226,0.0003026496,0.9963648,0.00001399159,0.001591791,0.000002891632],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9733513,0.004993122,0.01583513,0.0001731519,0.0001464166,0.0001867561,0.001278438,0.0005906774,0.003445088],"genre_scores_gemma":[0.9764546,0.002419108,0.01313214,0.0001528117,0.00002396384,0.0001222895,0.001301729,0.00008767901,0.006305603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001080388,"threshold_uncertainty_score":0.003614306,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02102856543162459,"score_gpt":0.2597916898164744,"score_spread":0.2387631243848498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}