{"id":"W2891611582","doi":"10.1371/journal.pgen.1007668","title":"Topoisomerases I and III inhibit R-loop formation to prevent unregulated replication in the chromosomal Ter region of Escherichia coli","year":2018,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; College of Engineering, Michigan State University; National Institutes of Health; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Genome Canada; University of Toronto; Michigan State University","keywords":"Biology; Topoisomerase; DNA gyrase; Mutant; DNA replication; Molecular biology; DNA; Topoisomerase IV; Origin of replication; SeqA protein domain; DNA supercoil; Escherichia coli; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009651679,0.00008072002,0.00008016402,0.00002975915,0.00003764364,0.00001283056,0.0001014055,0.00007134145,0.000003644],"category_scores_gemma":[0.0000124184,0.00006651135,0.0000203258,0.000108438,0.00004309059,0.000003046037,0.00005387224,0.00003153115,0.000001140581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001083415,"about_ca_system_score_gemma":0.00002451637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007574039,"about_ca_topic_score_gemma":0.00008209769,"domain_scores_codex":[0.9993895,0.00003803838,0.0001818955,0.0001879285,0.0000921295,0.0001104677],"domain_scores_gemma":[0.9994502,0.000005058623,0.00007542154,0.0003592754,0.00008066679,0.00002939921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000586119,0.00008629092,0.00008633525,0.00001489362,0.00001306412,2.94719e-7,0.0005012682,0.00001078812,0.9957416,0.00008323168,0.0001356487,0.003267975],"study_design_scores_gemma":[0.0002865491,0.0006438514,0.0006878192,0.00002461909,0.0000197694,0.000006996542,0.0001061825,0.0007116295,0.9932176,0.000154369,0.004055314,0.00008523613],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980344,0.0003520685,0.0007414846,0.0003323206,0.00003344625,0.0003937267,0.000004873887,0.000003840654,0.0001038726],"genre_scores_gemma":[0.9985975,0.0002175843,0.00033137,0.0005925994,0.0001082408,0.00004097785,0.00003068712,0.00001014071,0.00007092446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003919666,"threshold_uncertainty_score":0.2712254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02102856543162459,"score_gpt":0.2597916898164744,"score_spread":0.2387631243848498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}