{"id":"W2891621105","doi":"10.3389/fimmu.2018.02036","title":"Physiological Stimuli Induce PAD4-Dependent, ROS-Independent NETosis, With Early and Late Events Controlled by Discrete Signaling Pathways","year":2018,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":159,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Neutrophil extracellular traps; Cell biology; Signal transduction; Syk; p38 mitogen-activated protein kinases; Chromatin; Biology; MAPK/ERK pathway; Inflammation; Kinase; Immunology; Biochemistry; Tyrosine kinase; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001184487,0.0003559113,0.0002343628,0.0001102307,0.0001026061,0.0002085305,0.0001304281,0.0001595228,0.001411114],"category_scores_gemma":[0.00008555714,0.00007441424,0.0002619315,0.00008029662,0.0001634653,0.0001388764,0.0002166715,0.0004345195,0.0003209705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002019239,"about_ca_system_score_gemma":0.0001518527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001485327,"about_ca_topic_score_gemma":0.0002518525,"domain_scores_codex":[0.9998763,0.00002520644,0.00001357888,0.00002402876,0.00002602536,0.00003488997],"domain_scores_gemma":[0.9999591,0.000009494586,0.00001113793,0.000005037399,0.000004251116,0.00001101436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003165647,0.00004450083,0.0002127609,0.0000692871,0.000005790725,0.00004905158,0.000007463714,0.0000602515,0.9978382,0.00007591086,0.00002890711,0.001291353],"study_design_scores_gemma":[0.00001829656,0.0003625194,0.002879115,0.000004115535,0.000007602566,0.0001089495,0.00001332274,0.0004510736,0.9950303,0.00002216216,0.001100814,0.000001828931],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915407,0.001865396,0.004490063,0.0001018108,0.00003689447,0.00005829,0.0004404152,0.00006878137,0.00139759],"genre_scores_gemma":[0.9944707,0.0007769827,0.002514782,0.00005572396,0.00001096381,0.00007186762,0.0005474324,0.000009021172,0.001542537],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001411114,"threshold_uncertainty_score":0.004720628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01283774459322994,"score_gpt":0.2206062147071403,"score_spread":0.2077684701139104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}