{"id":"W2891622817","doi":"10.3389/fonc.2018.00411","title":"Ibrutinib Resistance Is Reduced by an Inhibitor of Fatty Acid Oxidation in Primary CLL Lymphocytes","year":2018,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Faculty of Medicine, McGill University; McGill University; Leukemia and Lymphoma Society","keywords":"Ibrutinib; Chronic lymphocytic leukemia; Bruton's tyrosine kinase; Cancer research; Beta oxidation; Glutaminolysis; Idelalisib; Biochemistry; Leukemia; Pharmacology; Medicine; Metabolism; Tyrosine kinase; Chemistry; Biology; Glycolysis; Signal transduction; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000775842,0.0001788688,0.0006869459,0.0003949366,0.0000376571,0.00000757344,0.0002644449,0.000407066,0.0001343888],"category_scores_gemma":[0.000386573,0.0001792113,0.00005464677,0.0006133927,0.0006527422,0.0001715889,0.000101039,0.0002578536,0.00002025136],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.02625325,"about_ca_system_score_gemma":0.007964964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003346112,"about_ca_topic_score_gemma":0.0002961236,"domain_scores_codex":[0.9976606,0.0002555851,0.0006526189,0.000522195,0.0003854747,0.0005235061],"domain_scores_gemma":[0.9988312,0.0001082016,0.0001937876,0.0005427636,0.0001711441,0.0001529757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00933551,0.001141535,0.0263782,0.0004629625,0.00007700622,0.0001776568,0.003834223,0.000002008894,0.5069139,0.00004773364,0.4198067,0.03182261],"study_design_scores_gemma":[0.04245862,0.002871969,0.01489127,0.0003477531,0.00003908547,0.0000568283,0.001134812,0.0024135,0.8703215,0.0005572988,0.06456298,0.0003444356],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849067,0.001413956,0.0006770763,0.0009128567,0.000767562,0.0006273009,0.00002162286,0.00003195191,0.01064096],"genre_scores_gemma":[0.9647927,0.0003456519,0.0312591,0.0009671506,0.0003438007,0.00007081712,0.000115324,0.00004072191,0.002064695],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3634076,"threshold_uncertainty_score":0.997659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01633979250244916,"score_gpt":0.3192178389115551,"score_spread":0.3028780464091059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}