{"id":"W2891622817","doi":"10.3389/fonc.2018.00411","title":"Ibrutinib Resistance Is Reduced by an Inhibitor of Fatty Acid Oxidation in Primary CLL Lymphocytes","year":2018,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Faculty of Medicine, McGill University; McGill University; Leukemia and Lymphoma Society","keywords":"Ibrutinib; Chronic lymphocytic leukemia; Bruton's tyrosine kinase; Cancer research; Beta oxidation; Glutaminolysis; Idelalisib; Biochemistry; Leukemia; Pharmacology; Medicine; Metabolism; Tyrosine kinase; Chemistry; Biology; Glycolysis; Signal transduction; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001352261,0.0003381328,0.0005092688,0.000265713,0.000151113,0.0003401969,0.0001833734,0.0002473177,0.002357225],"category_scores_gemma":[0.0001496561,0.0001308071,0.0002977858,0.0002331625,0.0001056649,0.00009678369,0.0001892051,0.0005308978,0.0006881868],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002546362,"about_ca_system_score_gemma":0.0001574418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008604873,"about_ca_topic_score_gemma":0.001195994,"domain_scores_codex":[0.9998145,0.00003494369,0.00001678072,0.00003277253,0.00003460833,0.0000664309],"domain_scores_gemma":[0.9999187,0.00001765661,0.00001157573,0.00001138107,0.00001544775,0.00002525308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000422238,0.00009318774,0.0002931417,0.00003723798,0.000007697261,0.00007748216,0.0000217657,0.00006033177,0.9965051,0.00002127456,0.0001360171,0.002324575],"study_design_scores_gemma":[0.0001353736,0.003022205,0.01258728,0.00001960176,0.00005724752,0.0007413119,0.0000711277,0.0006222566,0.977635,0.00004564836,0.005053288,0.000009633702],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936851,0.002812169,0.0008683074,0.0001150336,0.00004024821,0.00004071235,0.0007952622,0.0001290938,0.001513969],"genre_scores_gemma":[0.9932991,0.00139497,0.0009904163,0.0001323186,0.00001850627,0.00008808168,0.001604555,0.00003517105,0.002436928],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002357225,"threshold_uncertainty_score":0.007885695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01633979250244916,"score_gpt":0.3192178389115551,"score_spread":0.3028780464091059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}