{"id":"W2891623176","doi":"10.1016/j.phymed.2018.09.025","title":"Berberine inhibits hepatitis C virus entry by targeting the viral E2 glycoprotein","year":2018,"lang":"en","type":"article","venue":"Phytomedicine","topic":"Berberine and alkaloids research","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"Ministry of Science and Technology, Taiwan","keywords":"Hepatitis C virus; Viral entry; Virology; Glycoprotein; CD81; Virus; Hepacivirus; Biology; Lipid bilayer fusion; Viral replication; Molecular biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008825856,0.0003269908,0.000292179,0.0001374833,0.0001700259,0.0002126697,0.0001529129,0.000297523,0.001836306],"category_scores_gemma":[0.0001036503,0.00009393283,0.0001720124,0.00007700999,0.0001943499,0.0002442002,0.0001277465,0.0004187608,0.0004853517],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002347922,"about_ca_system_score_gemma":0.0001751951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008008407,"about_ca_topic_score_gemma":0.001935629,"domain_scores_codex":[0.9999405,0.0000170078,0.000003012821,0.000007405679,0.000008922073,0.00002311885],"domain_scores_gemma":[0.999964,0.00001284558,0.000006244031,0.000004416593,0.000004548525,0.000008033413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007208978,0.0001834432,0.000124732,0.0001503404,0.00001613473,0.00007455239,0.00002957807,0.0001145889,0.9921222,0.0001704555,0.0002733496,0.00601978],"study_design_scores_gemma":[0.0002489364,0.002374645,0.005549378,0.00002218731,0.00003414546,0.000382638,0.00004159267,0.001198559,0.9821716,0.0001488529,0.007815692,0.00001163486],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982024,0.009465041,0.001731164,0.0003106647,0.0001069553,0.00004282839,0.0001143921,0.0001202855,0.006084643],"genre_scores_gemma":[0.9875144,0.003724681,0.001200671,0.0001054787,0.00004624027,0.00001507031,0.0001836614,0.00001917278,0.007190666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001836306,"threshold_uncertainty_score":0.006143034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01115556401432352,"score_gpt":0.2916123298589635,"score_spread":0.28045676584464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}