{"id":"W2891682331","doi":"10.1016/j.celrep.2018.08.027","title":"Granule-Dependent NK Cell Killing of Cryptococcus Requires Kinesin to Reposition the Cytolytic Machinery for Directed Cytotoxicity","year":2018,"lang":"en","type":"article","venue":"Cell Reports","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Innovates - Health Solutions","keywords":"Microtubule; Microtubule organizing center; Cryptococcus neoformans; Cell biology; Biology; Perforin; Cytolysis; Kinesin; Organelle; Dynein; Granule (geology); Immunological synapse; Cytotoxicity; Microbiology; Cell; Centrosome; Immunology; Immune system; T cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004606418,0.0001732291,0.0003493126,0.0001089278,0.0003006983,0.00002060792,0.00005003407,0.00007834012,0.00004103473],"category_scores_gemma":[0.0002772539,0.000115206,0.000168727,0.000245329,0.0001063544,0.00004548356,0.00005634718,0.0001127833,0.000008296201],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007579626,"about_ca_system_score_gemma":0.0000613371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002548545,"about_ca_topic_score_gemma":0.00005114993,"domain_scores_codex":[0.9984981,0.00003692021,0.000619736,0.000354132,0.0002459236,0.0002452259],"domain_scores_gemma":[0.998461,0.0001460593,0.0003238159,0.0005296669,0.0004439407,0.00009550182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002498562,0.0003324473,0.009861232,0.0003347691,0.00005055184,0.000191082,0.0005533794,0.0000529651,0.982941,0.00001408358,0.004987048,0.0004315257],"study_design_scores_gemma":[0.0004379383,0.0008071035,0.01181883,0.0001668826,0.0002098742,0.0002974051,0.0001107508,0.0004819157,0.9824632,0.0002674057,0.002770146,0.0001684907],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9788683,0.000305382,0.006508635,0.0002706233,0.0007229076,0.001475759,0.000008304294,0.0001267619,0.01171331],"genre_scores_gemma":[0.995438,0.00003299863,0.001215608,0.000162705,0.0004605221,0.0001582918,0.00001484395,0.00002785035,0.002489134],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01656973,"threshold_uncertainty_score":0.4697965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01796152187487781,"score_gpt":0.2782652707508213,"score_spread":0.2603037488759435,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}