{"id":"W2891710133","doi":"10.1038/s41598-018-32250-3","title":"Time course of focused ultrasound effects on β-amyloid plaque pathology in the TgCRND8 mouse model of Alzheimer’s disease","year":2018,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Canada Research Chairs","keywords":"Ultrasound; Alzheimer's disease; Medicine; In vivo; Magnetic resonance imaging; Amyloid (mycology); Pathology; Focused ultrasound; Disease; Radiology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005957018,0.0001278677,0.0001949015,0.0001092364,0.00008286071,0.00002673298,0.0001817434,0.00005842777,0.00002937792],"category_scores_gemma":[0.0000702356,0.00009417507,0.00007441195,0.0002842079,0.0004089506,0.00006267933,0.00001283254,0.00009499701,0.00002516936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001352488,"about_ca_system_score_gemma":0.00006786878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004936101,"about_ca_topic_score_gemma":0.00001462859,"domain_scores_codex":[0.9988537,0.00004082843,0.0003637393,0.0002964788,0.0002396487,0.00020558],"domain_scores_gemma":[0.9986924,0.0001531811,0.0001127444,0.0009013659,0.00007308801,0.0000672008],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001197839,0.0002304623,0.0007794222,0.0000419853,0.00003128308,0.00002792381,0.001870143,0.01261673,0.9793585,0.0002370145,0.00406858,0.0007259856],"study_design_scores_gemma":[0.000469645,0.0001182915,0.005525113,0.00009749646,0.0001785236,0.00007261502,0.0001292603,0.03517699,0.9445166,0.01133358,0.001964691,0.0004171952],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997516,0.0001366211,0.0003112193,0.00004912197,0.0003960233,0.0003909533,0.00003098913,0.00005585796,0.001113247],"genre_scores_gemma":[0.9994199,0.000005636569,0.0002103682,0.00002556132,0.00004105227,0.00005576388,0.00003489897,0.00002017658,0.0001866346],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0348419,"threshold_uncertainty_score":0.3840348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01295840438437153,"score_gpt":0.2324980122618832,"score_spread":0.2195396078775116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}