{"id":"W2891747209","doi":"10.1186/s40659-018-0182-7","title":"Increased ROS production and DNA damage in monocytes are biomarkers of aging and atherosclerosis","year":2018,"lang":"en","type":"article","venue":"Biological Research","topic":"Atherosclerosis and Cardiovascular Diseases","field":"Immunology and Microbiology","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Fundação de Amparo à Pesquisa e Inovação do Espírito Santo; Conselho Nacional de Desenvolvimento Científico e Tecnológico","keywords":"Oxidative stress; Apolipoprotein E; Proinflammatory cytokine; DNA damage; Apoptosis; Immunology; Monocyte; Reactive oxygen species; Apolipoprotein B; Inflammation; Biology; Medicine; Endocrinology; Internal medicine; DNA; Cell biology; Cholesterol; Genetics; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001487579,0.0001100808,0.0002557476,0.0001323398,0.0001774264,0.00001817257,0.0001256047,0.0001901665,0.0001084092],"category_scores_gemma":[0.001013835,0.00007835952,0.00005796219,0.0002595766,0.001622456,0.00005350785,0.0002273592,0.0001771808,0.00001692503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002377154,"about_ca_system_score_gemma":0.00002151691,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000233372,"about_ca_topic_score_gemma":0.00004784864,"domain_scores_codex":[0.9982342,0.0007697932,0.0001826435,0.0004115432,0.00006668621,0.0003351876],"domain_scores_gemma":[0.9993417,0.0002200639,0.00004806394,0.0002249299,0.000125219,0.00004007562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001081521,0.00008118097,0.3515327,0.00001667787,0.00006053513,5.576196e-7,0.00008035226,4.346747e-8,0.6442941,0.00007315395,0.0001554938,0.003597032],"study_design_scores_gemma":[0.0004254591,0.0002505552,0.8584536,0.000103689,0.000007826296,0.000002668282,0.0006201423,0.000002947379,0.1394742,0.0001097652,0.0004663822,0.00008272308],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943424,0.005052852,0.000005520593,0.0001277358,0.00004911425,0.0002639817,0.00001923523,0.0000212429,0.0001179244],"genre_scores_gemma":[0.9981418,0.001673523,0.00003400187,0.00001769881,0.00003565153,0.00003302884,0.000009900401,0.000007673506,0.00004675896],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5069209,"threshold_uncertainty_score":0.5978009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1003374516419389,"score_gpt":0.3289111103941789,"score_spread":0.22857365875224,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}