{"id":"W2891747209","doi":"10.1186/s40659-018-0182-7","title":"Increased ROS production and DNA damage in monocytes are biomarkers of aging and atherosclerosis","year":2018,"lang":"en","type":"article","venue":"Biological Research","topic":"Atherosclerosis and Cardiovascular Diseases","field":"Immunology and Microbiology","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Fundação de Amparo à Pesquisa e Inovação do Espírito Santo; Conselho Nacional de Desenvolvimento Científico e Tecnológico","keywords":"Oxidative stress; Apolipoprotein E; Proinflammatory cytokine; DNA damage; Apoptosis; Immunology; Monocyte; Reactive oxygen species; Apolipoprotein B; Inflammation; Biology; Medicine; Endocrinology; Internal medicine; DNA; Cell biology; Cholesterol; Genetics; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000470257,0.0004309256,0.0003825593,0.0007875871,0.0001688768,0.0002687789,0.0001439264,0.0003349038,0.0006788562],"category_scores_gemma":[0.0002813224,0.0001629479,0.0001861906,0.0004690463,0.0002205279,0.0002122325,0.000248822,0.0004759267,0.00015296],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001134503,"about_ca_system_score_gemma":0.0001746486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002336993,"about_ca_topic_score_gemma":0.0003757503,"domain_scores_codex":[0.9996485,0.00009053387,0.00003706138,0.00006719134,0.0001024,0.00005440418],"domain_scores_gemma":[0.9995365,0.00004735504,0.0002285225,0.00003032379,0.00007929154,0.00007803179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002423901,0.0001862539,0.0442414,0.000522121,0.000101707,0.000431686,0.0002400136,0.00006405538,0.9338191,0.0001491974,0.0001059404,0.01771454],"study_design_scores_gemma":[0.00006455908,0.004647246,0.6402164,0.0001356475,0.0003033915,0.003166147,0.0004357458,0.0004332114,0.3456513,0.0007882424,0.004120024,0.00003812042],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9496029,0.04409712,0.004712981,0.0001423911,0.00008823979,0.00005641033,0.000398868,0.00003933962,0.0008617966],"genre_scores_gemma":[0.9854821,0.009686762,0.003082971,0.00009080642,0.00009521405,0.00006201797,0.0003484799,0.000004170762,0.00114753],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007875871,"threshold_uncertainty_score":0.002486944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1003374516419389,"score_gpt":0.3289111103941789,"score_spread":0.22857365875224,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}