{"id":"W2891759256","doi":"10.1200/jco.2017.35.15_suppl.7503","title":"A genetic risk-stratified, randomized phase 2 intergroup study of fludarabine/antibody combinations in symptomatic, untreated chronic lymphocytic leukemia (CLL): Results from Cancer and Leukemia Group B (CALGB) 10404 (Alliance).","year":2017,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen Elizabeth II Health Sciences Centre","funders":"","keywords":"Medicine; Chemoimmunotherapy; Fludarabine; Internal medicine; Chronic lymphocytic leukemia; Rituximab; Cyclophosphamide; Obinutuzumab; Gastroenterology; Randomized controlled trial; Interim analysis; Regimen; IGHV@; Lenalidomide; Oncology; Leukemia; Surgery; Multiple myeloma; Chemotherapy; Lymphoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.007237734,0.0004380643,0.004731849,0.0003508097,0.0002049093,0.00008046897,0.0008485705,0.0007011069,0.0001339284],"category_scores_gemma":[0.01868192,0.000324392,0.0006077441,0.0002620659,0.001546111,0.000316914,0.0003219294,0.001673952,0.00001439425],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.03900868,"about_ca_system_score_gemma":0.04903737,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0298181,"about_ca_topic_score_gemma":0.01248147,"domain_scores_codex":[0.9889201,0.002043729,0.006747611,0.0006991147,0.0009807827,0.0006086541],"domain_scores_gemma":[0.9809332,0.01004452,0.006587461,0.001146771,0.0006476012,0.0006403654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7127039,0.01398538,0.03699873,0.0006045661,0.008268531,0.005998031,0.003656454,0.002908728,0.003652631,0.0001813233,0.001617747,0.209424],"study_design_scores_gemma":[0.7613896,0.01543539,0.09068237,0.001010305,0.00166894,0.0001463104,0.0003007998,0.1281825,0.00009771506,0.0006773223,0.0001761483,0.0002325742],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935566,0.002021969,0.0001764168,0.0005167483,0.001009125,0.002002629,0.00006388167,0.00002077191,0.0006318291],"genre_scores_gemma":[0.9862314,0.01179191,0.0008977219,0.00009088255,0.0006561024,0.0000728927,0.00002393759,0.00005004746,0.0001850828],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2091914,"threshold_uncertainty_score":0.9999208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07279910882673507,"score_gpt":0.4713194874257098,"score_spread":0.3985203785989747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}