{"id":"W2891792998","doi":"10.1007/978-1-4939-8645-3_3","title":"Serpin Phage Display: The Use of a T7 System to Probe Reactive Center Loop Libraries with Different Serine Proteinases","year":2018,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; Canadian Blood Services; University of Toronto","funders":"","keywords":"Serpin; Phage display; Bacteriophage; Protein engineering; Hypervariable region; Capsid; Biology; Computational biology; Phagemid; Molecular biology; Virus; Biochemistry; Genetics; Escherichia coli; Antibody; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003780781,0.0004929657,0.0003987979,0.0002837256,0.0002416845,0.0006973814,0.0004080468,0.0004734409,0.001329569],"category_scores_gemma":[0.0003224654,0.0002377558,0.0003705765,0.0002709484,0.0002433319,0.0002890024,0.0004257101,0.001088969,0.0006004631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003109915,"about_ca_system_score_gemma":0.0001913676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003147115,"about_ca_topic_score_gemma":0.0006566247,"domain_scores_codex":[0.9996614,0.00006640345,0.00001551388,0.00008163511,0.0001079231,0.00006701188],"domain_scores_gemma":[0.9998579,0.00004524347,0.00002178663,0.00002206985,0.00001966738,0.00003324841],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006439316,0.00001289933,0.00005332025,0.00001542154,0.000003968674,0.000016603,0.00001062744,0.00005449447,0.9981745,0.00008912515,0.00003366281,0.001471033],"study_design_scores_gemma":[0.000004847699,0.00006956446,0.0002513637,0.000001176318,0.000005500322,0.00007350597,0.000004854124,0.0006590016,0.998217,0.0000277331,0.0006821115,0.000003347415],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.9074303,0.0007777432,0.08657279,0.0001727998,0.00005558537,0.0001173867,0.0004262718,0.000792175,0.00365497],"genre_scores_gemma":[0.9444717,0.0007661972,0.04787307,0.0002175128,0.0000214245,0.0000895768,0.001017508,0.0001763001,0.005366692],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.001329569,"threshold_uncertainty_score":0.004447877,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05803383427505731,"score_gpt":0.3992068671911623,"score_spread":0.341173032916105,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}