{"id":"W2891812864","doi":"10.1016/j.pupt.2018.09.005","title":"Pharmacokinetics and safety of a single dose of the novel LAMA/LABA fixed-dose combination of glycopyrronium/formoterol fumarate dihydrate metered dose inhaler, formulated using co-suspension delivery technology, in Japanese healthy subjects","year":2018,"lang":"en","type":"article","venue":"Pulmonary Pharmacology & Therapeutics","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"CMC Microsystems; AstraZeneca","keywords":"Cmax; Pharmacokinetics; Metered-dose inhaler; Fixed-dose combination; Medicine; Formoterol; Pharmacology; Formoterol Fumarate; Bronchodilator; COPD; Inhaler; Indacaterol; Crossover study; Area under the curve; Anesthesia; Inhalation; Internal medicine; Asthma; Budesonide","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007864105,0.0007494725,0.00137858,0.0002575807,0.0003074413,0.0004919404,0.0004519945,0.0009122846,0.0009378104],"category_scores_gemma":[0.0009546307,0.0006088777,0.0009244058,0.0002582828,0.0007745033,0.0007411749,0.0002376731,0.001613688,0.0003181142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006348874,"about_ca_system_score_gemma":0.0006676663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001489754,"about_ca_topic_score_gemma":0.002329102,"domain_scores_codex":[0.9995017,0.0001883123,0.00003252726,0.000129714,0.00007078664,0.00007699698],"domain_scores_gemma":[0.9994791,0.00006871867,0.0001488628,0.00005803925,0.00004849439,0.0001968041],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6863064,0.04006346,0.01575636,0.0005554844,0.001435691,0.0002872221,0.0005424857,0.001764298,0.1885111,0.0001021023,0.001171699,0.06350365],"study_design_scores_gemma":[0.09216259,0.8139934,0.07231086,0.00002392081,0.00152894,0.0003612237,0.0001734997,0.002824564,0.01472449,0.00009401332,0.001706155,0.00009634739],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987385,0.0005283356,0.0002010928,0.0000364868,0.00002184887,0.0001318648,0.0001141956,0.00002107664,0.0002065867],"genre_scores_gemma":[0.9983327,0.0002579721,0.0003699805,0.000121613,0.00004418327,0.0001554671,0.0001947356,0.000006877663,0.0005165225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001489754,"threshold_uncertainty_score":0.004606485,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03865490223905419,"score_gpt":0.3255238133373472,"score_spread":0.286868911098293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}