{"id":"W2891826418","doi":"10.1111/bjh.15571","title":"Safety and efficacy of vismodegib in relapsed/refractory acute myeloid leukaemia: results of a phase Ib trial","year":2018,"lang":"en","type":"letter","venue":"British Journal of Haematology","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Princess Margaret Cancer Centre","funders":"National Cancer Institute; F. Hoffmann-La Roche","keywords":"Medicine; Refractory (planetary science); Internal medicine; Oncology; Myeloid leukaemia; Vismodegib; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0009917429,0.000333111,0.00183577,0.0002866322,0.00005435771,0.00001397776,0.0004566509,0.001398239,0.000008770829],"category_scores_gemma":[0.001461422,0.0003632426,0.0003543379,0.0001248284,0.0007581215,0.000007342144,0.0002157343,0.00129584,0.000001156759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003446158,"about_ca_system_score_gemma":0.0004293057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006509593,"about_ca_topic_score_gemma":0.00005799083,"domain_scores_codex":[0.9961112,0.0005156525,0.002176004,0.0004660242,0.000324442,0.0004067464],"domain_scores_gemma":[0.9966071,0.0002758274,0.002172316,0.0003568809,0.0005098746,0.0000780515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.1057262,0.001239968,0.00004483877,0.0007485049,0.002651181,0.04440348,0.0004856501,0.00001436819,0.06374792,0.00000616043,0.7712802,0.009651455],"study_design_scores_gemma":[0.3000138,0.01634208,0.0001859757,0.003700746,0.001059459,0.08536302,0.0001146439,0.00001021893,0.06068804,0.0001739897,0.5312347,0.001113288],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810482,0.01016932,0.0001163916,0.006753455,0.0008172988,0.0003816258,0.0004597051,0.000004409713,0.0002496047],"genre_scores_gemma":[0.9507489,0.02147569,0.001865527,0.01811827,0.00627326,0.00002022925,0.0006264654,0.0002206701,0.0006510376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2400455,"threshold_uncertainty_score":0.9998981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01730731835137789,"score_gpt":0.2859015892973599,"score_spread":0.268594270945982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}