{"id":"W2891853104","doi":"10.1002/chem.201802677","title":"Multifunctional Compounds for Activation of the p53‐Y220C Mutant in Cancer","year":2018,"lang":"en","type":"article","venue":"Chemistry - A European Journal","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Simon Fraser University; Michael Smith Health Research BC","keywords":"Cytotoxicity; Mutant; Apoptosis; Cancer cell; Chemistry; Intracellular; Cisplatin; Cell culture; Cell biology; Cancer; In vitro; Cancer research; Biophysics; Biochemistry; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003206399,0.000100211,0.0001379292,0.00002860783,0.00009971773,0.00001342962,0.0001242265,0.00003492176,0.0002541275],"category_scores_gemma":[0.0001918219,0.00007440345,0.0001186477,0.0001524838,0.0001334164,0.00003497484,0.00003475231,0.0003540112,0.000003859285],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002265,"about_ca_system_score_gemma":0.0002551778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005358421,"about_ca_topic_score_gemma":0.000002025937,"domain_scores_codex":[0.9991374,0.0000450698,0.0003066983,0.0001383472,0.0002139472,0.0001585223],"domain_scores_gemma":[0.9992371,0.00002436523,0.0002221348,0.0001815875,0.0002565686,0.00007830859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003406884,0.00008509295,0.0009570297,0.00005835898,0.00005021983,0.00001266276,0.0002009829,0.00009468711,0.993053,0.000002394477,0.002468483,0.002676378],"study_design_scores_gemma":[0.004999486,0.0001613904,0.0193854,0.0008643377,0.00007674261,0.0006416405,0.000133708,0.003464921,0.9312085,0.00002727753,0.03889931,0.000137291],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922302,0.00009358275,0.001810389,0.000764302,0.0003586391,0.0001574584,0.00001668269,0.00001128175,0.004557462],"genre_scores_gemma":[0.9978308,0.00001721093,0.0003969245,0.000189597,0.0009783414,0.000004809295,0.000007826172,0.00002944618,0.0005450232],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06184454,"threshold_uncertainty_score":0.3034085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02785852652974055,"score_gpt":0.2738236775092412,"score_spread":0.2459651509795007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}