{"id":"W2891879622","doi":"10.1371/journal.pone.0203781","title":"A genetic mosaic screen identifies genes modulating Notch signaling in Drosophila","year":2018,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Chinese Universities Scientific Fund; Institute of Genetics; National Natural Science Foundation of China","keywords":"Notch signaling pathway; Hes3 signaling axis; Biology; Drosophila melanogaster; Notch proteins; Signal transduction; Cell biology; Genetics; Gene; Transcription factor; Multicellular organism; Genetic screen; Phenotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001187069,0.0004487827,0.0002444485,0.0008627105,0.0001894537,0.0002065109,0.0002857287,0.0003526325,0.001822764],"category_scores_gemma":[0.0001247818,0.0002136629,0.0002236926,0.0003368476,0.0002131091,0.0001016272,0.0002665714,0.0002483551,0.0004074509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002849289,"about_ca_system_score_gemma":0.0001714268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008253342,"about_ca_topic_score_gemma":0.001858903,"domain_scores_codex":[0.999823,0.00001449341,0.00001912427,0.0000575075,0.0000519013,0.00003408539],"domain_scores_gemma":[0.9998431,0.00003630091,0.00004975573,0.00001380339,0.00001054185,0.00004654608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002828372,0.000008134246,0.0002512057,0.000006718319,0.000002779968,0.00007881482,0.000004816822,0.00001345941,0.9990894,0.00005367953,0.0000146862,0.0004481005],"study_design_scores_gemma":[0.00003627578,0.0002336867,0.03283484,0.000007922818,0.00004702764,0.001311911,0.00004688018,0.001247999,0.9614606,0.0001034765,0.002656929,0.00001242124],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919488,0.0006036378,0.003331469,0.0000675672,0.00001214467,0.00005661081,0.001964077,0.0002016245,0.001813934],"genre_scores_gemma":[0.9875892,0.0004233367,0.004633637,0.000075101,0.000005105368,0.00005265187,0.002883338,0.00007303633,0.004264788],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001822764,"threshold_uncertainty_score":0.006097794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02474234051912626,"score_gpt":0.2342547960738752,"score_spread":0.209512455554749,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}