{"id":"W2891882631","doi":"10.15252/emmm.201809155","title":"Systematic pharmacological screens uncover novel pathways involved in cerebral cavernous malformations","year":2018,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Vascular Malformations Diagnosis and Treatment","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Agence Nationale de la Recherche; Fondation pour la Recherche Médicale; Deutsche Forschungsgemeinschaft; E-Rare","keywords":"Library science; German; Art history; Art; History; Computer science; Archaeology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002465032,0.000580959,0.0004748373,0.0005367415,0.000272627,0.0004524129,0.0002902347,0.0003364047,0.001860462],"category_scores_gemma":[0.0002018488,0.0002192294,0.000465571,0.000333145,0.0002988666,0.0001656204,0.0002423752,0.0007084906,0.0003305354],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004444251,"about_ca_system_score_gemma":0.0005706314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001267721,"about_ca_topic_score_gemma":0.005091659,"domain_scores_codex":[0.9998364,0.00001853095,0.00001335037,0.00003461635,0.00005921066,0.00003782344],"domain_scores_gemma":[0.9998678,0.00004373575,0.00003494878,0.00001338634,0.00002010689,0.00001994524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001531932,0.00007374548,0.000612197,0.0001071608,0.00004416552,0.0001573472,0.00001705316,0.0005612422,0.9920201,0.0002811507,0.0002120671,0.005760792],"study_design_scores_gemma":[0.0001180686,0.001199655,0.009297903,0.00002309291,0.0002387304,0.0006416146,0.00006817798,0.003054772,0.9759046,0.0002431284,0.009178798,0.00003133477],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9752944,0.004264334,0.01109764,0.0004581663,0.00006691149,0.0002809127,0.00308958,0.0005114683,0.004936573],"genre_scores_gemma":[0.9794993,0.005916291,0.008475092,0.0003342415,0.00001486237,0.0002297951,0.002266516,0.00006132747,0.003202605],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001860462,"threshold_uncertainty_score":0.006223917,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03202648105932199,"score_gpt":0.2882171036417138,"score_spread":0.2561906225823918,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}