{"id":"W2891907584","doi":"10.2147/dddt.s172538","title":"Macrocyclic lactones inhibit nasopharyngeal carcinoma cells proliferation through PAK1 inhibition and reduce in vivo tumor growth","year":2018,"lang":"en","type":"article","venue":"Drug Design Development and Therapy","topic":"Parasitic Diseases Research and Treatment","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institut National de la Santé et de la Recherche Médicale","keywords":"Nasopharyngeal carcinoma; In vivo; Cytotoxic T cell; Medicine; Cancer research; Cancer; Pharmacology; Cytotoxicity; In vitro; Immunology; Biology; Radiation therapy; Internal medicine; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001988232,0.0002067343,0.0002395609,0.0001326272,0.0001556497,0.00005686711,0.00003097972,0.00004374597,0.00005650666],"category_scores_gemma":[0.00001194117,0.0001649484,0.00002369976,0.000170123,0.0001316771,0.0002045257,0.00002213981,0.00008789403,0.0000218123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008329628,"about_ca_system_score_gemma":0.0002381364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004609209,"about_ca_topic_score_gemma":0.00001206159,"domain_scores_codex":[0.9987234,0.00009576926,0.0002454429,0.0003508356,0.0002614013,0.0003231363],"domain_scores_gemma":[0.9995311,0.00005511336,0.00004876246,0.00009873119,0.00008706342,0.0001792363],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01712136,0.008066347,0.2702954,0.0005841246,0.0006788979,0.002328927,0.03874412,6.056609e-7,0.5871537,0.001283366,0.007994422,0.06574871],"study_design_scores_gemma":[0.008716801,0.0003789537,0.04069148,0.0001115032,0.0000144013,0.00005146192,0.000137514,0.00005733917,0.9479403,0.0006846744,0.00102102,0.0001945399],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961167,0.001582815,0.0001848963,0.0004116982,0.00004134602,0.001012382,0.000005264313,0.00003601776,0.0006088595],"genre_scores_gemma":[0.994957,0.0009663268,0.002861484,0.0004593022,0.0001088128,0.0001697032,0.00003267923,0.00002034155,0.0004242919],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3607866,"threshold_uncertainty_score":0.6726399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03305226841364001,"score_gpt":0.2948139527346176,"score_spread":0.2617616843209776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}