{"id":"W2891907584","doi":"10.2147/dddt.s172538","title":"Macrocyclic lactones inhibit nasopharyngeal carcinoma cells proliferation through PAK1 inhibition and reduce in vivo tumor growth","year":2018,"lang":"en","type":"article","venue":"Drug Design Development and Therapy","topic":"Parasitic Diseases Research and Treatment","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institut National de la Santé et de la Recherche Médicale","keywords":"Nasopharyngeal carcinoma; In vivo; Cytotoxic T cell; Medicine; Cancer research; Cancer; Pharmacology; Cytotoxicity; In vitro; Immunology; Biology; Radiation therapy; Internal medicine; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004380763,0.0003432445,0.0001739562,0.0001750141,0.00007573544,0.0001078377,0.0001292467,0.0001299938,0.001953306],"category_scores_gemma":[0.00006662872,0.00005867681,0.0001690317,0.0001097576,0.0001239763,0.0001096329,0.0001044056,0.0002999261,0.0003110544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001527991,"about_ca_system_score_gemma":0.0001603028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004844243,"about_ca_topic_score_gemma":0.001192579,"domain_scores_codex":[0.999972,0.00000474275,0.000002379929,0.00000523338,0.000006753593,0.000008863801],"domain_scores_gemma":[0.9999651,0.000004974896,0.00001338108,0.000003045958,0.000004411197,0.000009196338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004952293,0.0001410562,0.0003932683,0.0001858672,0.00001210246,0.00005477403,0.00001411794,0.0002838729,0.9886209,0.0000580045,0.0001789765,0.00956174],"study_design_scores_gemma":[0.00007867104,0.00416546,0.005891324,0.00001780382,0.00002883058,0.0001832846,0.00002197179,0.0005251149,0.9845837,0.00003040531,0.004467719,0.000005689988],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985047,0.00884711,0.001474912,0.0001413058,0.00004120271,0.00007667887,0.0006614304,0.0001481152,0.003562294],"genre_scores_gemma":[0.9917783,0.004069584,0.001073371,0.0000663739,0.000009152512,0.00004901648,0.0004175211,0.00001023918,0.002526488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001953306,"threshold_uncertainty_score":0.006534457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03305226841364001,"score_gpt":0.2948139527346176,"score_spread":0.2617616843209776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}