{"id":"W2891960083","doi":"10.1021/acssensors.8b00697","title":"Discovery of Butyrylcholinesterase-Activated Near-Infrared Fluorogenic Probe for Live-Cell and<i>In Vivo</i>Imaging","year":2018,"lang":"en","type":"article","venue":"ACS Sensors","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Central China Normal University; Natural Science Foundation of Hubei Province; Ministry of Science and Technology of the People's Republic of China; National Natural Science Foundation of China","keywords":"Butyrylcholinesterase; Acetylcholinesterase; Zebrafish; In vivo; Chemistry; Cell biology; Biochemistry; Enzyme; Biology; Aché; Biotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008182759,0.0002125649,0.0003696783,0.0001115555,0.00007119477,0.00004113085,0.00006339169,0.00005266494,0.00002395722],"category_scores_gemma":[0.0001680959,0.0001852325,0.0001024541,0.0001994811,0.0001826688,0.000261648,0.00004269259,0.00009234909,0.000005569138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002317773,"about_ca_system_score_gemma":0.0001000398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002934175,"about_ca_topic_score_gemma":0.00001078728,"domain_scores_codex":[0.9987883,0.00004997666,0.0003545233,0.0003830188,0.0001454824,0.0002786963],"domain_scores_gemma":[0.9991203,0.0001564434,0.000114577,0.0002967543,0.0002095317,0.0001024047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009991815,0.0002690586,0.05385281,0.0001772886,0.00002428867,0.00003383055,0.0006118491,0.00000477515,0.9432551,0.000007567402,0.0005748289,0.0001894851],"study_design_scores_gemma":[0.002820902,0.000218361,0.01582249,0.0001627101,0.00009915387,0.00003799034,0.0001748695,0.0007754606,0.9788343,0.00002495442,0.0008404663,0.0001883316],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982392,0.0003194934,0.00006131997,0.000211765,0.00009855429,0.0007182023,0.0001345922,0.0000387166,0.0001781244],"genre_scores_gemma":[0.9968969,0.00006320159,0.0005785406,0.0007669702,0.0002272401,0.0000368715,0.00004424022,0.00004479904,0.001341217],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03803032,"threshold_uncertainty_score":0.7553563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01840495545410028,"score_gpt":0.27681313585255,"score_spread":0.2584081803984498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}