{"id":"W2891968006","doi":"10.3389/fimmu.2018.02162","title":"Rapamycin as an Adjunctive Therapy for NLRC4 Associated Macrophage Activation Syndrome","year":2018,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"NLRC4; Inflammasome; Macrophage activation syndrome; Anakinra; Medicine; Adjunctive treatment; Macrophage; Secretion; Inflammation; Immunology; Caspase 1; Internal medicine; Biology; In vitro; Disease; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002241894,0.0001857554,0.0002344792,0.0001394331,0.0001312621,0.00001558302,0.0002622938,0.000394658,0.00003881318],"category_scores_gemma":[0.0001664193,0.0001915735,0.00008734317,0.0001555961,0.0002387562,0.00001795196,0.00004706744,0.0001278896,0.00001094488],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005493269,"about_ca_system_score_gemma":0.00009448121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006023857,"about_ca_topic_score_gemma":0.00002721087,"domain_scores_codex":[0.9987878,0.0001480773,0.0002285715,0.0003807851,0.00006158651,0.0003932169],"domain_scores_gemma":[0.9993572,0.00001100589,0.0001200407,0.0003432024,0.0001432262,0.00002536382],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003110069,0.0003253569,0.00530652,0.000004953486,0.0004991583,0.000004395507,0.0006330915,0.000006485216,0.9571844,0.0001237381,0.006710561,0.02609123],"study_design_scores_gemma":[0.008073982,0.008011147,0.07640561,0.0000217934,0.00001938537,0.0000190325,0.001401414,0.0001435551,0.8271223,0.003386425,0.07480495,0.0005903593],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931129,0.001242161,0.003315597,0.00009197934,0.001025672,0.0004865825,0.00001578014,0.00002160143,0.0006877295],"genre_scores_gemma":[0.9964426,0.0003619692,0.0009625255,0.0004632965,0.00008492723,0.0001292084,0.0006355863,0.00003796556,0.000881878],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1300621,"threshold_uncertainty_score":0.781214,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005840555668466479,"score_gpt":0.2378628961010674,"score_spread":0.2320223404326009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}