{"id":"W2891992691","doi":"10.1038/s41388-018-0464-0","title":"Premature activation of Cdk1 leads to mitotic events in S phase and embryonic lethality","year":2018,"lang":"en","type":"article","venue":"Oncogene","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Biomedical Research Council; Institute of Molecular and Cell Biology; National Medical Research Council; Medical Research Council; Agency for Science, Technology and Research","keywords":"Biology; Cell biology; Cyclin-dependent kinase 1; Mitosis; DNA damage; Cell cycle; Premature chromosome condensation; Wee1; Cell cycle checkpoint; Embryonic stem cell; DNA repair; Cyclin B1; Synthetic lethality; Cancer research; Genetics; Cell; DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000111159,0.00008067255,0.0001098244,0.00003563574,0.00001971335,0.000002650743,0.00007544409,0.0001146847,0.00001064895],"category_scores_gemma":[0.00005643462,0.00007918129,0.00002674143,0.00008035753,0.00003209216,0.000002810861,0.00006258431,0.00004125944,0.000003311288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001341908,"about_ca_system_score_gemma":0.00003850765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002153995,"about_ca_topic_score_gemma":0.0001325698,"domain_scores_codex":[0.9994587,0.00003369943,0.0001275724,0.0002014251,0.00005787222,0.0001207703],"domain_scores_gemma":[0.9996405,0.000004401908,0.00004963711,0.0001977931,0.00006355628,0.00004407997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001180225,0.0001093752,0.002797221,0.00002404353,0.00001174224,2.569013e-7,0.0000595866,0.000005162623,0.9937955,0.00001019635,0.0002838348,0.002785128],"study_design_scores_gemma":[0.00077477,0.0003985631,0.005672751,0.00002664437,0.000008495676,0.00000319406,0.00001776874,0.00003246262,0.9886389,0.00002817769,0.00430707,0.0000911555],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998535,0.0001776635,0.0006644782,0.000104647,0.00006401255,0.0001702323,0.00001549709,0.000002726614,0.0002657064],"genre_scores_gemma":[0.998795,0.00005295252,0.0004982013,0.0001801718,0.0001335601,0.000007924968,0.00005517651,0.000009488941,0.000267487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005156483,"threshold_uncertainty_score":0.322892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01081140323032151,"score_gpt":0.2919058716351507,"score_spread":0.2810944684048292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}