{"id":"W2891993073","doi":"10.1136/bmjopen-2018-025317","title":"Real-world health services utilisation and outcomes after <i>BRCA1</i> and <i>BRCA2</i> testing in Ontario, Canada: the What Comes Next Cohort Study protocol","year":2018,"lang":"en","type":"article","venue":"BMJ Open","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"North York General Hospital; Sunnybrook Health Science Centre; Sinai Health System; Institute for Clinical Evaluative Sciences; University of Toronto; Health Sciences Centre; Lunenfeld-Tanenbaum Research Institute; St. Michael's Hospital","funders":"Ontario Ministry of Health and Long-Term Care; Institute for Clinical Evaluative Sciences; American College of Surgeons","keywords":"Medicine; Breast cancer; Genetic testing; Cohort; Family medicine; Incidence (geometry); Health care; Cancer; Retrospective cohort study; Test (biology); Cohort study; Gynecology; Gerontology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005291276,0.001660628,0.001568623,0.002547764,0.005728837,0.002792804,0.003822219,0.001544107,0.01152327],"category_scores_gemma":[0.00769961,0.001483039,0.00303475,0.005961857,0.001434896,0.001243276,0.001887707,0.001854129,0.002069587],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.07205524,"about_ca_system_score_gemma":0.1400615,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9731677,"about_ca_topic_score_gemma":0.9829997,"domain_scores_codex":[0.9962181,0.0006539151,0.0006760413,0.0005948088,0.0008388424,0.001018226],"domain_scores_gemma":[0.9929635,0.0002754827,0.0009456479,0.0004089692,0.004475718,0.0009306639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00742227,0.002392841,0.6307899,0.008917361,0.001865714,0.001155487,0.009319153,0.005056618,0.0009941187,0.006549262,0.2833624,0.042175],"study_design_scores_gemma":[0.003900681,0.0009155425,0.8871058,0.004005217,0.000722671,0.0001985875,0.004416997,0.00353241,0.0004989572,0.001301216,0.09308963,0.0003122769],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"dataset","genre_gemma":"protocol","genre_scores_codex":[0.1320107,0.001343246,0.003742887,0.00193565,0.000205943,0.3340918,0.5086789,0.000218303,0.01777253],"genre_scores_gemma":[0.2481681,0.001670861,0.01299531,0.001949331,0.0001408936,0.5818556,0.1438024,0.00006346194,0.009354074],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.07205524,"threshold_uncertainty_score":0.5227998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04595465998310175,"score_gpt":0.3734329388711721,"score_spread":0.3274782788880703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}