{"id":"W2892021652","doi":"10.3390/molecules23092315","title":"Hexanoic, Octanoic and Decanoic Acids Promote Basal and Insulin-Induced Phosphorylation of the Akt-mTOR Axis and a Balanced Lipid Metabolism in the HepG2 Hepatoma Cell Line","year":2018,"lang":"en","type":"article","venue":"Molecules","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"Fonds de recherche du Québec – Nature et technologies; Fonds Québécois de la Recherche sur la Nature et les Technologies; Université du Québec à Montréal","keywords":"Steatosis; Insulin resistance; Decanoic acid; PI3K/AKT/mTOR pathway; Protein kinase B; Fatty liver; Endocrinology; Insulin; Internal medicine; Lipid metabolism; Biology; Chemistry; Biochemistry; Phosphorylation; Apoptosis; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001106915,0.0003305927,0.0002223148,0.0001828728,0.0001428189,0.0002616187,0.00009590476,0.0001238287,0.002449902],"category_scores_gemma":[0.00005489655,0.0001432515,0.0002627804,0.0002288979,0.000144444,0.0001516723,0.0002179339,0.0004080684,0.0007164764],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001721605,"about_ca_system_score_gemma":0.0002592922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001497937,"about_ca_topic_score_gemma":0.003008586,"domain_scores_codex":[0.9998648,0.00002253151,0.0000250155,0.00002604279,0.00003563067,0.0000258898],"domain_scores_gemma":[0.9999564,0.000007187808,0.000008933717,0.000007241731,0.000008875225,0.00001144447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007692043,0.0001114421,0.0003851746,0.0001074087,0.00001050996,0.00007574796,0.00003637184,0.00007544561,0.9965985,0.00006645604,0.0001298217,0.001633895],"study_design_scores_gemma":[0.0000370473,0.0006158753,0.007283711,0.00001514366,0.00001898941,0.0001965334,0.00009045968,0.0005741868,0.9865592,0.00005369586,0.004547401,0.000007860812],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859617,0.004181275,0.002146574,0.0002058158,0.0001249328,0.0000465238,0.001827288,0.0001078096,0.005397927],"genre_scores_gemma":[0.9808463,0.003686312,0.003277401,0.0001636413,0.00002317407,0.00008530651,0.002831836,0.00004190583,0.009044126],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002449902,"threshold_uncertainty_score":0.008195758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01014636829931781,"score_gpt":0.238336734825589,"score_spread":0.2281903665262712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}