{"id":"W2892042089","doi":"10.1016/j.ejps.2018.09.006","title":"Development of controlled release amorphous solid dispersions (CRASD) using polyvinyl acetate-based release retarding materials: Effect of dosage form design","year":2018,"lang":"en","type":"article","venue":"European Journal of Pharmaceutical Sciences","topic":"Drug Solubulity and Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"Patheon (Canada); University of Toronto","funders":"","keywords":"Dissolution; Polyvinylpyrrolidone; Polyvinyl acetate; Amorphous solid; Excipient; Dosage form; Solubility; Chemical engineering; Recrystallization (geology); Materials science; Polyvinyl alcohol; Precipitation; Chromatography; Dissolution testing; Controlled release; Chemistry; Polymer; Organic chemistry; Nanotechnology; Polymer chemistry; Biopharmaceutics Classification System","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0164507,0.0003403528,0.001031311,0.0003323038,0.0006638198,0.00005850412,0.0008327956,0.0001021799,0.0009162591],"category_scores_gemma":[0.0008509897,0.0002395026,0.0003155042,0.00051978,0.001697671,0.0003378175,0.0001525309,0.000528516,0.00005635073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001055729,"about_ca_system_score_gemma":0.0004821674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007346777,"about_ca_topic_score_gemma":0.000001327857,"domain_scores_codex":[0.9911566,0.005310996,0.001842621,0.0003295802,0.0007148737,0.000645321],"domain_scores_gemma":[0.9960032,0.001468573,0.001408894,0.0001722862,0.0003565463,0.0005904802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01217881,0.0004118255,0.0009888072,0.0002283683,0.0004092695,0.0002623176,0.001405255,0.003935233,0.9692908,0.00004693653,0.0004017077,0.01044067],"study_design_scores_gemma":[0.01042362,0.001802663,0.0002236986,0.0003615434,0.0006504487,0.0001223634,0.0002518664,0.03720189,0.9445208,0.00001336038,0.004129747,0.0002979788],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841549,0.0005807927,0.01138114,0.000193753,0.001855707,0.000576003,0.0000252976,0.00002668773,0.001205703],"genre_scores_gemma":[0.9932547,0.00006376423,0.005921769,0.0003096417,0.0003881307,0.000002592506,0.000001446641,0.0000265603,0.00003145895],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03326665,"threshold_uncertainty_score":0.999997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1884584679280855,"score_gpt":0.4422282342851118,"score_spread":0.2537697663570263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}