{"id":"W2892096656","doi":"10.1093/nar/gky807","title":"Misfolding of a DNAzyme for ultrahigh sodium selectivity over potassium","year":2018,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"National Natural Science Foundation of China","keywords":"Deoxyribozyme; G-quadruplex; DNA; Fluorescence; Biology; Mutant; Cleavage (geology); Biophysics; Selectivity; Sodium; Stacking; Biochemistry; Chemistry; Catalysis; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002630098,0.0004218559,0.000369019,0.0001406619,0.000145346,0.0004319927,0.0004010822,0.0005289281,0.0006139211],"category_scores_gemma":[0.0003849881,0.0002168532,0.000263945,0.0001319163,0.0002074534,0.0002980028,0.0002850132,0.0005153364,0.0005097118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003308415,"about_ca_system_score_gemma":0.0002356395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002911779,"about_ca_topic_score_gemma":0.0005919712,"domain_scores_codex":[0.9997173,0.00004089479,0.00002876029,0.0001054551,0.0000778055,0.00002977569],"domain_scores_gemma":[0.9997432,0.00003939984,0.00006827382,0.00003944841,0.00006183616,0.00004781947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001630984,0.000003855702,0.00005166735,0.00001700297,0.000002517685,0.00001421781,0.000007567681,0.00004529588,0.9990318,0.00003388615,0.00001007291,0.0007658358],"study_design_scores_gemma":[0.000002207757,0.00004178688,0.0001960327,0.000001156613,0.000002686957,0.00009082212,0.000003543528,0.0004373236,0.9986292,0.00001613794,0.0005767018,0.000002277107],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9580608,0.001342425,0.03876207,0.0002713861,0.00006200776,0.00005439673,0.000171783,0.0003553322,0.0009197702],"genre_scores_gemma":[0.9650816,0.0004670402,0.03089824,0.00009543893,0.000009628249,0.00003786597,0.0002318791,0.00007911728,0.003099122],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006139211,"threshold_uncertainty_score":0.002400398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03348022788474986,"score_gpt":0.3704347288725023,"score_spread":0.3369545009877525,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}