{"id":"W2892136519","doi":"10.1056/nejmoa1806382","title":"Phase 2 Trial of Selective Tyrosine Kinase 2 Inhibition in Psoriasis","year":2018,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":414,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Probity Medical Research","funders":"Bristol-Myers Squibb","keywords":"Placebo; Medicine; Psoriasis; Internal medicine; Psoriasis Area and Severity Index; Gastroenterology; Clinical endpoint; Tyrosine kinase 2; Clinical trial; Pharmacology; Immunology; Pathology; Receptor; Platelet-derived growth factor receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001490088,0.001559868,0.001887513,0.0004399528,0.0003220276,0.0006915164,0.0006023142,0.001361666,0.006959349],"category_scores_gemma":[0.000807656,0.0005323919,0.001012119,0.0003226339,0.0006961109,0.0006352896,0.0003430162,0.0026727,0.001039075],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000544281,"about_ca_system_score_gemma":0.001083584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005104776,"about_ca_topic_score_gemma":0.001043798,"domain_scores_codex":[0.9996107,0.000178192,0.0000169634,0.00006763225,0.00004443671,0.00008213026],"domain_scores_gemma":[0.9996023,0.00008026729,0.00008836797,0.00003154273,0.0000317411,0.0001658052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8051288,0.04329698,0.002632253,0.00159866,0.001158875,0.0003879125,0.0002158113,0.001812366,0.04293058,0.0006006978,0.008194494,0.0920426],"study_design_scores_gemma":[0.8858911,0.1080332,0.002091274,0.00003131555,0.0001420047,0.0001821444,0.00001777462,0.0005267917,0.001457394,0.000154172,0.00146367,0.000009147755],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838822,0.003956076,0.001369147,0.001133004,0.0003953055,0.004820618,0.001468655,0.0002352121,0.002739791],"genre_scores_gemma":[0.9772828,0.003367338,0.002593086,0.002374865,0.000524768,0.007310485,0.002532031,0.00003918747,0.003975546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006959349,"threshold_uncertainty_score":0.02328134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02193395392893607,"score_gpt":0.2897631125167306,"score_spread":0.2678291585877946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}