{"id":"W2892136519","doi":"10.1056/nejmoa1806382","title":"Phase 2 Trial of Selective Tyrosine Kinase 2 Inhibition in Psoriasis","year":2018,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":414,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Probity Medical Research","funders":"Bristol-Myers Squibb","keywords":"Placebo; Medicine; Psoriasis; Internal medicine; Psoriasis Area and Severity Index; Gastroenterology; Clinical endpoint; Tyrosine kinase 2; Clinical trial; Pharmacology; Immunology; Pathology; Receptor; Platelet-derived growth factor receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007866017,0.0001273463,0.0004855213,0.0003245051,0.00003846741,0.000001791996,0.00006537294,0.0001258472,0.0004250513],"category_scores_gemma":[0.0003698087,0.0000844897,0.00007105043,0.0002657251,0.00017795,0.00007621119,0.00001084659,0.0001814845,0.00001315706],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004114284,"about_ca_system_score_gemma":0.0001185615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001256074,"about_ca_topic_score_gemma":0.00009126941,"domain_scores_codex":[0.9988173,0.0002494863,0.0005858805,0.0001074911,0.00007583742,0.000164037],"domain_scores_gemma":[0.9990304,0.0002045307,0.0004112814,0.0001006957,0.0002097274,0.00004341777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1544443,0.001302389,0.0006119278,0.00001217007,0.0003219906,0.0001164753,0.002974687,0.000001149164,0.3892411,0.0001351048,0.009274225,0.4415645],"study_design_scores_gemma":[0.7143036,0.01964415,0.0009642267,0.0002317567,0.0002778579,0.0003358726,0.0001413608,8.366982e-7,0.2519875,0.0005586407,0.01147229,0.00008193759],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939419,0.002122078,0.0001387805,0.0007884546,0.002102189,0.0001503102,0.000008467098,0.00000564454,0.0007421699],"genre_scores_gemma":[0.9965216,0.0003156798,0.00008172391,0.00006091777,0.002719247,0.00000172317,0.00002109458,0.000007902736,0.0002701198],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5598593,"threshold_uncertainty_score":0.4654014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02193395392893607,"score_gpt":0.2897631125167306,"score_spread":0.2678291585877946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}