{"id":"W2892144284","doi":"10.1200/jco.2016.34.15_suppl.e21054","title":"Second-line drug regimens in metastatic melanoma patients based on BRAF mutation status: A Canadian real-world retrospective study.","year":2016,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada; Merck Canada Inc. (Canada)","funders":"","keywords":"Medicine; Metastatic melanoma; Oncology; Melanoma; Internal medicine; Retrospective cohort study; Targeted therapy; Metastasis; Mutation; Immunotherapy; Cancer; Cancer research; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007570685,0.0004581115,0.0005493127,0.001619977,0.001825449,0.001187982,0.0008684046,0.0005571519,0.002215757],"category_scores_gemma":[0.00252434,0.0006041172,0.0008217009,0.005493785,0.0005336417,0.0004960062,0.0008018249,0.0008881798,0.0003301395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01322511,"about_ca_system_score_gemma":0.0155379,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9129964,"about_ca_topic_score_gemma":0.9386747,"domain_scores_codex":[0.9988128,0.00007496937,0.0001187491,0.000245608,0.0004491122,0.0002988409],"domain_scores_gemma":[0.9967726,0.0002273954,0.001405741,0.0001446797,0.0008921574,0.0005575361],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001004552,0.000038655,0.9970907,0.00006243336,0.00004682129,0.000144206,0.0002519397,0.00003437581,0.00009781361,0.00003710809,0.0006159839,0.001479476],"study_design_scores_gemma":[0.00002501477,0.00008961542,0.99629,0.00006685049,0.00006344361,0.0004544905,0.001082084,0.000211412,0.00006623278,0.00002182497,0.001611496,0.00001761099],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891214,0.001301593,0.0001033424,0.0001920343,0.00001059572,0.0001458877,0.007589123,0.000007104788,0.001528821],"genre_scores_gemma":[0.9949056,0.001033031,0.000199221,0.0002296239,0.00001323114,0.00005707891,0.003204461,0.000006200063,0.0003515784],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08700365,"threshold_uncertainty_score":0.175032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04291784905435145,"score_gpt":0.374787704850302,"score_spread":0.3318698557959505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}