{"id":"W2892173212","doi":"10.1101/421404","title":"Complex human gut microbiome cultured in anaerobic human intestine chips","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fundação para a Ciência e a Tecnologia; Defense Advanced Research Projects Agency; Hansjörg Wyss Institute for Biologically Inspired Engineering, Harvard University; Harvard University; Institute for Bioengineering and Biosciences; U.S. Food and Drug Administration; Hamilton Health Sciences Foundation; Bill and Melinda Gates Foundation","keywords":"Bacteroidetes; Biology; Microbiome; Human microbiome; Firmicutes; Mucus; Obligate anaerobe; Microbiology; Gut flora; Anaerobic bacteria; Bacteroides thetaiotaomicron; Bacteria; Anaerobic exercise; Bacteroides; Immunology; Ecology; Bioinformatics; Physiology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003842609,0.0003182558,0.0003024369,0.0001991962,0.0002014466,0.0004363169,0.0002433783,0.000281261,0.00112681],"category_scores_gemma":[0.0003390593,0.0002078452,0.0002245872,0.0001968364,0.0002001098,0.0001970469,0.0004892484,0.000232495,0.0004267242],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001517548,"about_ca_system_score_gemma":0.0002793052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008120118,"about_ca_topic_score_gemma":0.001097064,"domain_scores_codex":[0.9996607,0.0000568529,0.00002776264,0.0001151112,0.00008785485,0.00005173421],"domain_scores_gemma":[0.9998684,0.00004040311,0.00002568682,0.0000218557,0.00002675126,0.00001686879],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001461472,0.00002765415,0.001766964,0.00008491165,0.00001634883,0.00007877881,0.00007754518,0.0006037724,0.9931726,0.0001699021,0.0002587602,0.003596589],"study_design_scores_gemma":[0.00002425612,0.000339545,0.01361152,0.00003066027,0.00005926894,0.000328882,0.0001303764,0.007262167,0.9682586,0.0002198084,0.009705734,0.00002923936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9125138,0.001546159,0.07763905,0.0002660198,0.00016097,0.0002331879,0.00357398,0.0004837995,0.003582984],"genre_scores_gemma":[0.8721706,0.001336815,0.1167564,0.0004044692,0.00005648647,0.0005062693,0.004787229,0.000102283,0.003879444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00112681,"threshold_uncertainty_score":0.003769517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02402345246826616,"score_gpt":0.2688472475857778,"score_spread":0.2448237951175117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}