{"id":"W2892256324","doi":"10.1200/jco.2019.37.15_suppl.3123","title":"Phase 1b study of selinexor, a first-in-class selective inhibitor of nuclear export (SINE) compound, in combination with doxorubicin in patients (pts) with locally advanced or metastatic soft tissue sarcoma (STS).","year":2019,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Neutropenia; Tolerability; Internal medicine; Doxorubicin; Febrile neutropenia; Adverse effect; Anemia; Phases of clinical research; Metastatic breast cancer; Gastroenterology; Clinical endpoint; Surgery; Toxicity; Breast cancer; Oncology; Chemotherapy; Cancer; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008295592,0.0001517972,0.0009671723,0.000176098,0.00001257388,0.000003824883,0.0001435114,0.0001807383,0.00001737887],"category_scores_gemma":[0.0003561339,0.0001022818,0.00006201788,0.0002735216,0.00009520581,0.00002531448,0.00004193461,0.0004170929,0.000001216278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007577431,"about_ca_system_score_gemma":0.000368405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004726764,"about_ca_topic_score_gemma":0.002018493,"domain_scores_codex":[0.9974074,0.000334422,0.001576156,0.0002440338,0.000272282,0.000165646],"domain_scores_gemma":[0.9976713,0.0002230451,0.001412446,0.0001638733,0.0004596094,0.00006969136],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1654602,0.06315079,0.68773,0.0001518119,0.0005057617,0.0002972341,0.001122296,0.002652569,0.02181499,0.00002070957,0.0002975885,0.05679602],"study_design_scores_gemma":[0.1787152,0.4100628,0.4009672,0.0002750903,0.0001605136,0.00006475509,0.002203214,0.0006197815,0.002395422,0.00005167934,0.004192148,0.0002921974],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988691,0.00002588277,0.00008740869,0.0001085122,0.0001931525,0.0006256654,0.000002903134,0.000001565171,0.00008587197],"genre_scores_gemma":[0.9982278,0.00002516117,0.001505974,0.0001383762,0.00004860653,0.000003511071,0.000008625525,0.00002149476,0.00002045438],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.346912,"threshold_uncertainty_score":0.4170932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01959332846466126,"score_gpt":0.3483013990197485,"score_spread":0.3287080705550872,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}