{"id":"W2892256324","doi":"10.1200/jco.2019.37.15_suppl.3123","title":"Phase 1b study of selinexor, a first-in-class selective inhibitor of nuclear export (SINE) compound, in combination with doxorubicin in patients (pts) with locally advanced or metastatic soft tissue sarcoma (STS).","year":2019,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Neutropenia; Tolerability; Internal medicine; Doxorubicin; Febrile neutropenia; Adverse effect; Anemia; Phases of clinical research; Metastatic breast cancer; Gastroenterology; Clinical endpoint; Surgery; Toxicity; Breast cancer; Oncology; Chemotherapy; Cancer; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001307718,0.001278438,0.001361166,0.0003971591,0.0002989287,0.000579702,0.0006465969,0.0009194424,0.004112835],"category_scores_gemma":[0.0007305782,0.000629007,0.0007610549,0.000345002,0.0007533622,0.0005995516,0.0003115156,0.002226094,0.000848573],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006734126,"about_ca_system_score_gemma":0.001255022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007672313,"about_ca_topic_score_gemma":0.002339584,"domain_scores_codex":[0.9996792,0.0001827039,0.00001309994,0.00004537965,0.00002949133,0.00005021671],"domain_scores_gemma":[0.9994767,0.000106782,0.0001132161,0.00003249557,0.00003036854,0.0002404262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5300225,0.1741343,0.01817242,0.001489136,0.001503493,0.0007800151,0.0008479412,0.008126006,0.1355477,0.0005681706,0.006255962,0.1225524],"study_design_scores_gemma":[0.3089336,0.6587967,0.01937314,0.00003851645,0.0002890616,0.0006141242,0.00008934095,0.002807091,0.006219238,0.0002264198,0.002578655,0.00003415563],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948004,0.000879245,0.0006156296,0.000318734,0.00003388752,0.001619771,0.0007273559,0.00006053746,0.0009442957],"genre_scores_gemma":[0.9911922,0.001091363,0.00164591,0.0004279759,0.00006247561,0.001644046,0.001625014,0.00002678556,0.002284219],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004112835,"threshold_uncertainty_score":0.01375884,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01959332846466126,"score_gpt":0.3483013990197485,"score_spread":0.3287080705550872,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}