{"id":"W2892263168","doi":"10.1080/2162402x.2018.1512943","title":"Identification of PD-L2, B7-H3 and CTLA-4 immune checkpoint proteins in genetic subtypes of meningioma","year":2018,"lang":"en","type":"article","venue":"OncoImmunology","topic":"Meningioma and schwannoma management","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; Institute of Cancer Research; University of Calgary","funders":"Government of Canada; Health Research Board","keywords":"Immunotherapy; Immune checkpoint; Cancer research; Meningioma; Medicine; Immune system; CTLA-4; Mutation; PD-L1; Gene; Immunology; Biology; T cell; Pathology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003990308,0.0001163901,0.0004009652,0.0003103045,0.00003120524,0.000004936177,0.0001167764,0.0001088997,0.00009996037],"category_scores_gemma":[0.0001130771,0.0001080509,0.00005250708,0.000270192,0.000357795,0.00004433277,0.0001053072,0.00008400669,0.00001733482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004046848,"about_ca_system_score_gemma":0.00004714615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002799441,"about_ca_topic_score_gemma":0.000020535,"domain_scores_codex":[0.9986561,0.00007338121,0.0007038817,0.0002369153,0.00013446,0.0001952926],"domain_scores_gemma":[0.9990749,0.00002778022,0.0003160005,0.0004221601,0.0001326884,0.00002641275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003528462,0.000176973,0.01660931,0.0001560998,0.0001043566,0.00005054322,0.001160238,6.917531e-7,0.9736652,0.0007737618,0.00001853931,0.006931456],"study_design_scores_gemma":[0.001321466,0.001056209,0.5895092,0.0001119527,0.00006110052,0.00013039,0.0002878239,0.0001413176,0.4065891,0.0004033669,0.0003041956,0.00008381456],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946027,0.001901986,0.0002206817,0.0003246927,0.0001245996,0.0005109023,0.000001957028,0.00001763413,0.002294804],"genre_scores_gemma":[0.9975552,0.00004204347,0.00158341,0.000007080488,0.00003168501,0.00003879719,0.000007781186,0.00001256402,0.0007214269],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5728999,"threshold_uncertainty_score":0.4406189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01278036193971916,"score_gpt":0.2636774817306414,"score_spread":0.2508971197909222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}