{"id":"W2892305615","doi":"10.3390/ijms19092630","title":"Histone Deacetylase Inhibitors and Diabetic Kidney Disease","year":2018,"lang":"en","type":"review","venue":"International Journal of Molecular Sciences","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"Canadian Institutes of Health Research; Novo Nordisk; Kidney Foundation of Canada; Diabetes Canada; Banting and Best Diabetes Centre, University of Toronto; Heart and Stroke Foundation of Canada","keywords":"Histone deacetylase; Medicine; Epigenetics; Clinical trial; Disease; Bioinformatics; Pharmacology; Diabetes mellitus; Adverse effect; Histone deacetylase inhibitor; Repurposing; Kidney disease; Histone; Biology; Internal medicine; Endocrinology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000965008,0.000312662,0.0005447479,0.0005281762,0.0001098782,0.0001612607,0.001224705,0.0001830631,0.00003133409],"category_scores_gemma":[0.0010726,0.0002515797,0.0004899916,0.0002244255,0.001018341,0.00001979839,0.0004124964,0.0002863332,0.00002232435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001162301,"about_ca_system_score_gemma":0.001850777,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005642844,"about_ca_topic_score_gemma":0.00000161643,"domain_scores_codex":[0.9970708,0.000259119,0.0007419755,0.0004789323,0.001159534,0.0002896773],"domain_scores_gemma":[0.9979205,0.00004089225,0.0006839854,0.0002487263,0.000553204,0.0005526712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002433515,0.000706114,0.00006123668,0.003026065,0.001856232,0.002676679,0.0001660532,0.00002619806,0.01720609,0.0003819299,0.08012114,0.8935289],"study_design_scores_gemma":[0.0002843621,0.000355711,0.000002345359,0.002927046,0.0001603875,0.0004559699,0.00001009822,0.000006399476,0.004784523,0.00005683965,0.9906629,0.0002934391],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01293802,0.9847459,0.0001799117,0.0002657021,0.001367066,0.0001782278,0.0000589731,0.000004415779,0.0002618051],"genre_scores_gemma":[0.003558744,0.994041,0.0006366667,0.0002144592,0.001179824,0.00001168836,0.0000483231,0.00003859575,0.0002706854],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9105417,"threshold_uncertainty_score":0.9999936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02267354584138898,"score_gpt":0.3630696392174244,"score_spread":0.3403960933760354,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}