{"id":"W2892309170","doi":"10.1200/jco.2018.36.15_suppl.tps3120","title":"An open-label, multidrug, biomarker-directed, multicentre phase II umbrella study in patients with non-small cell lung cancer, who progressed on an anti-PD-1/PD-L1 containing therapy (HUDSON).","year":2018,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Medicine; Cancer; Biomarker; Lung cancer; PD-L1; Oncology; Internal medicine; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002451724,0.001693752,0.002230526,0.0003553398,0.0005331585,0.00109515,0.001260695,0.0014252,0.004383827],"category_scores_gemma":[0.001297962,0.0007036961,0.001354172,0.0005674639,0.0009672536,0.001096736,0.0008302372,0.00201365,0.001345821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001387908,"about_ca_system_score_gemma":0.001964483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001926403,"about_ca_topic_score_gemma":0.003464785,"domain_scores_codex":[0.9992148,0.0003798786,0.00002722681,0.0001866522,0.00005749998,0.0001338454],"domain_scores_gemma":[0.9983572,0.0001375109,0.0002758143,0.000167682,0.00009754328,0.0009641327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7799679,0.07052404,0.06777862,0.0004517162,0.001666366,0.0004320735,0.0003811022,0.001011365,0.02976624,0.0002116992,0.004833309,0.04297555],"study_design_scores_gemma":[0.5454892,0.3529895,0.09370594,0.00004007172,0.000668402,0.0004768863,0.0001651612,0.0008638978,0.001712854,0.000195273,0.003652328,0.00004042581],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934602,0.0008298005,0.0002739572,0.0003201693,0.00008032013,0.001922893,0.002018334,0.00004000085,0.001054328],"genre_scores_gemma":[0.9798775,0.0007697221,0.002257533,0.001500581,0.0002196728,0.004128222,0.007582839,0.00003324365,0.003630555],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004383827,"threshold_uncertainty_score":0.01466537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1098417638920332,"score_gpt":0.4874188813811434,"score_spread":0.3775771174891102,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}