{"id":"W2892324919","doi":"10.1371/journal.ppat.1007290","title":"Longitudinal transcriptomic characterization of the immune response to acute hepatitis C virus infection in patients with spontaneous viral clearance","year":2018,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Hepatitis C virus research","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; Alberta Innovates; Public Health Agency; Fonds de Recherche du Québec - Santé; Alberta Innovates - Health Solutions; Canadian Institutes of Health Research; Leona M. and Harry B. Helmsley Charitable Trust; Styrelsen för Internationellt Utvecklingssamarbete; National Institutes of Health; Public Health Agency of Canada; American Liver Foundation","keywords":"Innate immune system; Immune system; Immunology; Hepatitis C virus; Virology; Biology; Virus; Transcriptome; Dengue virus; Interferon; Dengue fever; Peripheral blood mononuclear cell; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000305618,0.0001331711,0.0003712801,0.0003854436,0.00022656,0.0005310144,0.0001142651,0.0002360606,0.0009727048],"category_scores_gemma":[0.0006957097,0.0001065475,0.0001666831,0.0004920203,0.0001896028,0.0001956896,0.000287619,0.0003372139,0.0002963648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001533099,"about_ca_system_score_gemma":0.0001634686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004655271,"about_ca_topic_score_gemma":0.0007830544,"domain_scores_codex":[0.9997912,0.0000384118,0.00001490105,0.00007012745,0.00003798182,0.00004729773],"domain_scores_gemma":[0.9996862,0.00008600722,0.00008371654,0.00002960931,0.00006300619,0.00005149743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002735444,0.0001202732,0.6392318,0.0002159264,0.000142998,0.0006162808,0.0008005087,0.0004676041,0.3259243,0.0001975069,0.0007742058,0.02877315],"study_design_scores_gemma":[0.00001405003,0.0004980778,0.9832477,0.00001922616,0.0000644044,0.0007209581,0.0005363948,0.001109382,0.0117489,0.0001937684,0.001833238,0.00001406844],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970844,0.000484019,0.0008085268,0.00004278769,0.000007231193,0.00001933323,0.001164034,0.0000161884,0.0003734921],"genre_scores_gemma":[0.9956173,0.0002825415,0.000895524,0.00008345024,0.00001756434,0.00005439623,0.002585905,0.00001210392,0.0004512347],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009727048,"threshold_uncertainty_score":0.003254056,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01339713470153843,"score_gpt":0.2547071970344087,"score_spread":0.2413100623328703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}