{"id":"W2892382386","doi":"10.21037/jtd.2018.09.80","title":"The need to move away from fecal transplant towards targeted, refined microbiome therapy","year":2018,"lang":"en","type":"letter","venue":"Journal of Thoracic Disease","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Microbiome; Fecal bacteriotherapy; Medicine; Feces; Intensive care medicine; Bioinformatics; Ecology; Microbiology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0007749576,0.0006413656,0.001110226,0.0005319971,0.0002732938,0.0002707201,0.001027978,0.0005789761,0.0007762676],"category_scores_gemma":[0.0003877591,0.0003831017,0.00117569,0.0005491769,0.0002589296,0.0000989445,0.0001137489,0.002783551,0.000267766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004343084,"about_ca_system_score_gemma":0.001829457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009020742,"about_ca_topic_score_gemma":0.000003516189,"domain_scores_codex":[0.9950765,0.0003570233,0.00119156,0.0005349247,0.001906712,0.000933232],"domain_scores_gemma":[0.9959627,0.0003601173,0.0005522873,0.001046049,0.0009410316,0.001137822],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0136599,0.0002957551,0.00009843349,0.0002393931,0.0009610709,0.007228098,0.0001586006,0.000001886959,0.01862206,5.631492e-7,0.9372861,0.02144807],"study_design_scores_gemma":[0.001635199,0.0009887562,0.002201399,0.001435934,0.0008715229,0.0002162424,0.00007044045,0.00001561457,0.02753237,0.00006114636,0.9644849,0.0004865149],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.3306247,0.006553827,0.00004921535,0.6589487,0.001386326,0.0007338834,0.001412437,0.00003545203,0.0002554427],"genre_scores_gemma":[0.189936,0.01095749,0.0009214635,0.7090313,0.06609799,0.0001056671,0.001934519,0.0006114216,0.02040415],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1406887,"threshold_uncertainty_score":0.9998621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02947624064056189,"score_gpt":0.3347177491620699,"score_spread":0.3052415085215081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}