{"id":"W2892431967","doi":"10.3324/haematol.2018.201194","title":"Highly sensitive methods are required to detect mutations in histiocytoses","year":2018,"lang":"en","type":"letter","venue":"Haematologica","topic":"Histiocytic Disorders and Treatments","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotel Dieu Hospital","funders":"","keywords":"Mutation; Erdheim–Chester disease; Genetics; Medicine; Cancer research; Computational biology; Biology; Histiocytosis; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001932271,0.0004409924,0.001276815,0.0004596109,0.0001238806,0.00002689129,0.0001369394,0.0007814295,0.0001900698],"category_scores_gemma":[0.001047386,0.0003483641,0.0001988252,0.0004418066,0.000211522,0.00003633037,0.00007477653,0.0006287133,0.0009210447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003663324,"about_ca_system_score_gemma":0.0001717427,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001518229,"about_ca_topic_score_gemma":0.00009914613,"domain_scores_codex":[0.9975895,0.0003297038,0.000516056,0.000747598,0.0003000516,0.0005170741],"domain_scores_gemma":[0.9984033,0.0004336425,0.0002510012,0.0005684527,0.000213144,0.0001305341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001772734,0.0001221567,0.0002830616,0.0002779416,0.0002466357,0.02688435,0.0004345485,0.000001570709,0.00005233763,0.00004974546,0.9664144,0.005055954],"study_design_scores_gemma":[0.002032473,0.001001137,0.003772192,0.001206613,0.0006891169,0.001676964,0.0002231051,0.00003597989,0.001466693,0.001964853,0.9852443,0.0006866264],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.04152735,0.001078141,0.008697747,0.8970752,0.001419917,0.004373411,0.0003942147,0.00067758,0.04475648],"genre_scores_gemma":[0.09962181,0.00006680222,0.186252,0.6958991,0.001102636,0.0007857696,0.001191088,0.0001772992,0.01490346],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.201176,"threshold_uncertainty_score":0.9998968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05598754510934373,"score_gpt":0.359167103244918,"score_spread":0.3031795581355743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}