{"id":"W2892431967","doi":"10.3324/haematol.2018.201194","title":"Highly sensitive methods are required to detect mutations in histiocytoses","year":2018,"lang":"en","type":"letter","venue":"Haematologica","topic":"Histiocytic Disorders and Treatments","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotel Dieu Hospital","funders":"","keywords":"Mutation; Erdheim–Chester disease; Genetics; Medicine; Cancer research; Computational biology; Biology; Histiocytosis; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001374364,0.0006599347,0.0006401892,0.0009938243,0.0008579771,0.001568204,0.0006105962,0.005660772,0.009262909],"category_scores_gemma":[0.008079046,0.0002910447,0.0005182178,0.0002906975,0.001331653,0.001356665,0.0005159506,0.007966611,0.006628928],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009165092,"about_ca_system_score_gemma":0.0004573033,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005825917,"about_ca_topic_score_gemma":0.0009650854,"domain_scores_codex":[0.9987265,0.0004482884,0.0001442595,0.0001057749,0.0003845209,0.0001905577],"domain_scores_gemma":[0.9946665,0.003356895,0.0003109697,0.0002565091,0.001023146,0.0003859035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003411562,0.0002931024,0.03470388,0.0007957756,0.00006375281,0.08971,0.000520336,0.0007385711,0.03687471,0.01167798,0.596353,0.2279277],"study_design_scores_gemma":[0.0001030144,0.0003284861,0.01982065,0.0009866263,0.00007782299,0.1278968,0.001833996,0.002198486,0.01728023,0.03675937,0.7926421,0.0000724438],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.02805155,0.02990715,0.02350641,0.8003428,0.03002168,0.0003446455,0.0004351732,0.0007204066,0.08667023],"genre_scores_gemma":[0.3323633,0.02455835,0.04492193,0.46884,0.07333598,0.0005138898,0.0005349321,0.0003079242,0.05462363],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.009262909,"threshold_uncertainty_score":0.03098756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05598754510934373,"score_gpt":0.359167103244918,"score_spread":0.3031795581355743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}