{"id":"W2892469985","doi":"10.1007/s12307-018-0218-0","title":"Hypoxia Induces the Acquisition of Cancer Stem-like Phenotype Via Upregulation and Activation of Signal Transducer and Activator of Transcription-3 (STAT3) in MDA-MB-231, a Triple Negative Breast Cancer Cell Line","year":2018,"lang":"en","type":"article","venue":"Cancer Microenvironment","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Cancer Society; Cure Brain Cancer Foundation; University of Alberta; Canadian Institutes of Health Research; Alberta Cancer Foundation; Women and Children's Health Research Institute; Children's Health Research Institute","keywords":"SOX2; STAT3; Cancer research; Cancer stem cell; Triple-negative breast cancer; Biology; Stem cell; Gene knockdown; Cancer cell; Downregulation and upregulation; Stem cell marker; Cell biology; Cell culture; Chemistry; Breast cancer; Transcription factor; Cancer; Signal transduction; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001440724,0.0002021091,0.0004291007,0.00008146895,0.0000509556,0.000005505422,0.00005984654,0.00008983707,0.0008334683],"category_scores_gemma":[0.0000010813,0.0001577501,0.00006717224,0.0001892798,0.000449296,0.0001765896,0.00001930452,0.0001154029,2.32464e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003306881,"about_ca_system_score_gemma":0.0001277672,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007905297,"about_ca_topic_score_gemma":0.001329495,"domain_scores_codex":[0.9986938,0.00006991309,0.0004659915,0.0003189055,0.0002630536,0.0001883734],"domain_scores_gemma":[0.99927,0.00003848277,0.0003625001,0.0001757623,0.00008057944,0.0000726952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001986782,0.0002178381,0.004003802,0.0003905692,0.00013305,2.306722e-7,0.004394569,0.0001505598,0.927325,0.000004191159,0.00004467732,0.06134879],"study_design_scores_gemma":[0.002815016,0.0002718292,0.2179067,0.0003764364,0.0002862522,0.000001637797,0.0006981826,0.000154401,0.7770271,0.00002329437,0.0003235668,0.0001155823],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913775,0.005987337,0.0004492305,0.0007857587,0.0001277162,0.0008178211,0.0004244884,0.00000451444,0.0000256324],"genre_scores_gemma":[0.9924234,0.006845556,0.0001526048,0.000157159,0.0001394192,0.0001280235,0.00001512496,0.00002514274,0.0001136299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2139029,"threshold_uncertainty_score":0.9987012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0141471454951872,"score_gpt":0.2462396062088409,"score_spread":0.2320924607136537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}