{"id":"W2892469985","doi":"10.1007/s12307-018-0218-0","title":"Hypoxia Induces the Acquisition of Cancer Stem-like Phenotype Via Upregulation and Activation of Signal Transducer and Activator of Transcription-3 (STAT3) in MDA-MB-231, a Triple Negative Breast Cancer Cell Line","year":2018,"lang":"en","type":"article","venue":"Cancer Microenvironment","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Cancer Society; Cure Brain Cancer Foundation; University of Alberta; Canadian Institutes of Health Research; Alberta Cancer Foundation; Women and Children's Health Research Institute; Children's Health Research Institute","keywords":"SOX2; STAT3; Cancer research; Cancer stem cell; Triple-negative breast cancer; Biology; Stem cell; Gene knockdown; Cancer cell; Downregulation and upregulation; Stem cell marker; Cell biology; Cell culture; Chemistry; Breast cancer; Transcription factor; Cancer; Signal transduction; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006904989,0.0001247646,0.0001917298,0.0001728459,0.0001542335,0.0002097551,0.00008173642,0.000145572,0.00141212],"category_scores_gemma":[0.00005337627,0.0001199279,0.0001748713,0.0001680549,0.0001126421,0.0001335269,0.00009288985,0.0003786368,0.0002792802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002413835,"about_ca_system_score_gemma":0.0002378393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003169588,"about_ca_topic_score_gemma":0.004865053,"domain_scores_codex":[0.9998947,0.000009966,0.000009584914,0.00001150653,0.00003624881,0.0000380537],"domain_scores_gemma":[0.9999532,0.000006709407,0.000009791174,0.000005248755,0.000006187584,0.00001889627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001380307,0.0000287852,0.0004470603,0.00001939765,0.000004195307,0.00007406394,0.00002678954,0.00003039595,0.9982413,0.0001026519,0.0001606978,0.000726646],"study_design_scores_gemma":[0.0000263152,0.0003456982,0.02292059,0.000003483544,0.00002024966,0.0005562119,0.0001189668,0.001113445,0.9706233,0.0000760357,0.004189479,0.000006244356],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958557,0.0009767346,0.0008290735,0.000146949,0.00002465169,0.00001409041,0.0007137501,0.00004391179,0.001394984],"genre_scores_gemma":[0.9951541,0.0004439683,0.0004602502,0.00006199213,0.000007297228,0.00002009006,0.001009195,0.000008453775,0.002834415],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003169588,"threshold_uncertainty_score":0.006302297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0141471454951872,"score_gpt":0.2462396062088409,"score_spread":0.2320924607136537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}