{"id":"W2892530831","doi":"10.1016/j.stem.2018.08.018","title":"Epigenetic Restoration of Fetal-like IGF1 Signaling Inhibits Leukemia Stem Cell Activity","year":2018,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; BC Cancer Agency","funders":"Canadian Institutes of Health Research; Fondazione CON IL SUD; Terry Fox Research Institute; Michael Smith Health Research BC","keywords":"Biology; Epigenetics; Stem cell; Cell biology; Leukemia; Fetus; Signal transduction; Cancer research; Immunology; Genetics; Pregnancy; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003906123,0.0002740231,0.0002610938,0.00008003173,0.0001498056,0.00003697679,0.0002308434,0.0003345389,0.00002535547],"category_scores_gemma":[0.00000373749,0.0002864889,0.0001396193,0.0001811247,0.000119294,0.00001037171,0.0001388445,0.0001306849,0.00006222527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006852331,"about_ca_system_score_gemma":0.0002045103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003988243,"about_ca_topic_score_gemma":0.00003595955,"domain_scores_codex":[0.9981971,0.0001916412,0.0004289554,0.0005634084,0.0002706537,0.0003482512],"domain_scores_gemma":[0.9985808,0.00003492583,0.0003977027,0.0005892296,0.0002573862,0.0001399617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007437616,0.00009945789,0.0006545411,0.0001432912,0.000009858125,0.000001235931,0.0001967272,0.0005555414,0.9932376,0.000001987428,0.0001691196,0.004856322],"study_design_scores_gemma":[0.0006045094,0.0006945888,0.0005154859,0.00002068043,0.00003837343,5.255183e-7,0.0001153947,0.0004726507,0.9894268,0.00002189298,0.007781961,0.0003071405],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9786338,0.002973417,0.008434338,0.000008493993,0.0004091149,0.0003282906,0.00001848839,0.00001823972,0.00917583],"genre_scores_gemma":[0.9938117,0.0003007912,0.0005652017,0.00002999128,0.0003407889,0.00001292843,0.00006050084,0.00005221341,0.004825936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01517786,"threshold_uncertainty_score":0.9999588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01512618516804704,"score_gpt":0.2323656764647189,"score_spread":0.2172394912966719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}