{"id":"W2892530831","doi":"10.1016/j.stem.2018.08.018","title":"Epigenetic Restoration of Fetal-like IGF1 Signaling Inhibits Leukemia Stem Cell Activity","year":2018,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; BC Cancer Agency","funders":"Canadian Institutes of Health Research; Fondazione CON IL SUD; Terry Fox Research Institute; Michael Smith Health Research BC","keywords":"Biology; Epigenetics; Stem cell; Cell biology; Leukemia; Fetus; Signal transduction; Cancer research; Immunology; Genetics; Pregnancy; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000213287,0.0002859107,0.0002183009,0.00029634,0.0001599504,0.0003714996,0.0003419435,0.0002596937,0.003100984],"category_scores_gemma":[0.0001913762,0.0001376247,0.0001817828,0.0001546238,0.0004149412,0.0001813482,0.0002377522,0.0008146883,0.0004372539],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004672545,"about_ca_system_score_gemma":0.0003531001,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001407136,"about_ca_topic_score_gemma":0.002565905,"domain_scores_codex":[0.9998296,0.00002680166,0.00001401055,0.00003902497,0.00003981263,0.00005057803],"domain_scores_gemma":[0.9998438,0.00003950385,0.00003732987,0.00002487694,0.00001074627,0.0000437279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003148769,0.00004221002,0.0003480336,0.00002481609,0.000006890267,0.0000467487,0.00001919494,0.0001556036,0.99443,0.0004694822,0.0001229552,0.004019165],"study_design_scores_gemma":[0.00001393272,0.0001451993,0.001457292,0.000002678966,0.000008389516,0.00007505493,0.00002835869,0.0004930049,0.9950687,0.00006482597,0.002639673,0.000002995362],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878212,0.001750976,0.005169678,0.0003472926,0.0001056548,0.00002544251,0.0008047821,0.0003166977,0.003658322],"genre_scores_gemma":[0.9957281,0.0002931842,0.0009067991,0.00005405908,0.000008339672,0.00001171188,0.0003246612,0.00002719465,0.002645938],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003100984,"threshold_uncertainty_score":0.01037383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01512618516804704,"score_gpt":0.2323656764647189,"score_spread":0.2172394912966719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}