{"id":"W2892569542","doi":"10.1016/j.molcel.2018.08.020","title":"Comprehensive Mapping of Histone Modifications at DNA Double-Strand Breaks Deciphers Repair Pathway Chromatin Signatures","year":2018,"lang":"en","type":"article","venue":"Molecular Cell","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":319,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Institute of General Medical Sciences; National Cancer Institute; Canadian Institutes of Health Research; Fundacja na rzecz Nauki Polskiej; Narodowe Centrum Nauki; Fondation pour la Recherche Médicale; Ligue Contre le Cancer; Agence Nationale de la Recherche","keywords":"Biology; Chromatin; Histone; DNA; Cell biology; DNA repair; Genetics; Computational biology; Histone code; Double strand; Nucleosome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001125591,0.0002431473,0.000239082,0.00007199748,0.0001230471,0.000011787,0.000281928,0.0002555386,0.00007380801],"category_scores_gemma":[0.00001692989,0.0002580693,0.0002503742,0.0001491077,0.0002308111,0.00000412776,0.0001823581,0.0000938735,0.00003567003],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000460763,"about_ca_system_score_gemma":0.00007836745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003139988,"about_ca_topic_score_gemma":0.00001979064,"domain_scores_codex":[0.9984814,0.00008362239,0.0003486109,0.0005398988,0.0002386676,0.0003077879],"domain_scores_gemma":[0.9986146,0.000012272,0.0001944106,0.0008192557,0.0002405619,0.0001189157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008514507,0.00009686414,0.00002075122,0.00006497756,0.00007620504,0.00001563326,0.0001738047,0.0001565173,0.9974544,0.0001268122,0.001459535,0.0002693625],"study_design_scores_gemma":[0.001079565,0.0002667018,0.0001504312,0.00002193272,0.00003076644,0.00001071956,0.00008546618,0.00030548,0.9629351,0.00006047115,0.03478996,0.0002633396],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9767151,0.001517752,0.009202575,0.00003890658,0.0001608074,0.0003971926,0.00003644443,0.00006623005,0.01186492],"genre_scores_gemma":[0.9906613,0.00002294027,0.007288116,0.0002252416,0.00007850977,0.00003427351,0.0001633782,0.00005092132,0.001475354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03451922,"threshold_uncertainty_score":0.9999871,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01400289613556426,"score_gpt":0.2551855146196655,"score_spread":0.2411826184841012,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}