{"id":"W2892646383","doi":"10.1016/j.actbio.2018.09.050","title":"Gene expression and protein synthesis of esterase from Streptococcus mutans are affected by biodegradation by-product from methacrylate resin composites and adhesives","year":2018,"lang":"en","type":"article","venue":"Acta Biomaterialia","topic":"Antimicrobial agents and applications","field":"Chemistry","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; University of Toronto","funders":"Ontario Ministry of Research and Innovation; National Institute of Dental and Craniofacial Research; Canadian Institutes of Health Research; Ontario Research Foundation","keywords":"Streptococcus mutans; Biofilm; Hydrolysis; Strain (injury); Methacrylate; Biodegradation; Esterase; Polymerization; Monomer; Materials science; Chemistry; Composite material; Bacteria; Enzyme; Polymer; Biochemistry; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004078089,0.0001984401,0.0002583516,0.00002644442,0.0001352341,0.0001033153,0.0001386319,0.0001132488,0.00030143],"category_scores_gemma":[0.00003396617,0.0001690979,0.00002164542,0.00007069406,0.0001974463,0.0001295217,0.0001005469,0.00002828558,0.000005075577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001169708,"about_ca_system_score_gemma":0.000008110759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001471431,"about_ca_topic_score_gemma":0.00002041481,"domain_scores_codex":[0.9989855,0.00005493846,0.000270553,0.0004541531,0.00009226191,0.000142649],"domain_scores_gemma":[0.9991956,0.00004412939,0.0002926819,0.000339357,0.00005867593,0.00006960538],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007722618,0.0001027889,0.00137477,0.00004727152,0.00005226305,8.662744e-7,0.0001318289,5.340246e-9,0.9936936,5.725802e-7,0.00404097,0.0004778531],"study_design_scores_gemma":[0.0003195445,0.00001618826,0.00297624,0.0002632592,0.00006408551,5.422222e-7,0.00005992526,0.00001273952,0.9954668,0.00004588859,0.0005816566,0.0001930751],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921128,0.0002267775,0.00002640636,0.0002144502,0.00005084955,0.0002397173,0.007061434,0.00005945903,0.000008164475],"genre_scores_gemma":[0.9962382,0.00004211481,0.002376294,0.00001141169,0.0001423193,0.0000512641,0.00103833,0.00002350518,0.00007652395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006023104,"threshold_uncertainty_score":0.6895611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008800449179569616,"score_gpt":0.2247735337285399,"score_spread":0.2159730845489703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}