{"id":"W2892646383","doi":"10.1016/j.actbio.2018.09.050","title":"Gene expression and protein synthesis of esterase from Streptococcus mutans are affected by biodegradation by-product from methacrylate resin composites and adhesives","year":2018,"lang":"en","type":"article","venue":"Acta Biomaterialia","topic":"Antimicrobial agents and applications","field":"Chemistry","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; University of Toronto","funders":"Ontario Ministry of Research and Innovation; National Institute of Dental and Craniofacial Research; Canadian Institutes of Health Research; Ontario Research Foundation","keywords":"Streptococcus mutans; Biofilm; Hydrolysis; Strain (injury); Methacrylate; Biodegradation; Esterase; Polymerization; Monomer; Materials science; Chemistry; Composite material; Bacteria; Enzyme; Polymer; Biochemistry; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002013329,0.0004070768,0.0003038925,0.0002741001,0.0001523141,0.0004139093,0.0001400485,0.0003418985,0.001102134],"category_scores_gemma":[0.0004115847,0.0002469224,0.0003713953,0.0002346487,0.0003303835,0.0003339219,0.0002192902,0.0003936698,0.0003190728],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002959289,"about_ca_system_score_gemma":0.0002407721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001138563,"about_ca_topic_score_gemma":0.0008863431,"domain_scores_codex":[0.9997676,0.00003605934,0.00002326195,0.00003880697,0.00005292193,0.00008142653],"domain_scores_gemma":[0.9997498,0.00009799163,0.0000520067,0.00001967918,0.00003417732,0.00004637196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002102385,0.00001660255,0.0001743103,0.000009457596,0.000001721545,0.00002367412,0.00001548305,0.0000273524,0.9990934,0.00002873451,0.000005462196,0.0003936905],"study_design_scores_gemma":[0.000004538193,0.000125271,0.003479852,0.000001483597,0.000006311704,0.00005695201,0.00003268614,0.0003755336,0.9956366,0.00003071516,0.0002470803,0.000002960412],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981716,0.0003191682,0.0008992826,0.00004183757,0.00001136528,0.000006647362,0.0001187282,0.0000194966,0.0004117742],"genre_scores_gemma":[0.9957587,0.0002511967,0.0009417682,0.00002112288,0.000009060343,0.00001626876,0.0003972049,0.00001827552,0.002586427],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001138563,"threshold_uncertainty_score":0.003686965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008800449179569616,"score_gpt":0.2247735337285399,"score_spread":0.2159730845489703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}