{"id":"W2892723308","doi":"10.1038/s41420-018-0103-0","title":"Inhibition of glioblastoma cell proliferation, invasion, and mechanism of action of a novel hydroxamic acid hybrid molecule","year":2018,"lang":"en","type":"article","venue":"Cell Death Discovery","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Hrvatska Zaklada za Znanost; Government of Canada","keywords":"Vorinostat; Temozolomide; Cancer research; HDAC6; Glioma; Buthionine sulfoximine; Pharmacology; Acetylation; Chemistry; Mechanism of action; Biology; Histone deacetylase; Biochemistry; Glutathione; Histone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006498484,0.0002323611,0.000124956,0.0001074752,0.00006786946,0.000110077,0.000134166,0.0001315354,0.0006570194],"category_scores_gemma":[0.00003151979,0.000054154,0.0001234282,0.00005431629,0.00009530316,0.0001017789,0.00009957589,0.0001550195,0.0001337249],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001634119,"about_ca_system_score_gemma":0.00008061955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002594849,"about_ca_topic_score_gemma":0.0004604433,"domain_scores_codex":[0.9999707,0.000005397974,0.000001964968,0.000005944571,0.000008932167,0.00000714185],"domain_scores_gemma":[0.9999871,0.000001719128,0.000003700681,0.000001403905,0.000002161534,0.000003900133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006319833,0.00002464655,0.00007905436,0.00003919626,0.000006356368,0.00002374534,0.000005105358,0.00007887573,0.9968148,0.0001791016,0.00002481904,0.002661129],"study_design_scores_gemma":[0.00003241156,0.0009335855,0.001807107,0.000003947098,0.00002111328,0.0002232683,0.000007498344,0.0007585778,0.9922773,0.00004052677,0.003891018,0.000003650131],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879938,0.004397025,0.004519238,0.00009162788,0.00003090686,0.00005216619,0.0001296671,0.00006575245,0.002719886],"genre_scores_gemma":[0.9950317,0.001493867,0.001969947,0.00003225856,0.000008023285,0.000026227,0.0001588786,0.000003894851,0.001275166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006570194,"threshold_uncertainty_score":0.002197981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01387966389674864,"score_gpt":0.2518165900318172,"score_spread":0.2379369261350685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}