{"id":"W2892723308","doi":"10.1038/s41420-018-0103-0","title":"Inhibition of glioblastoma cell proliferation, invasion, and mechanism of action of a novel hydroxamic acid hybrid molecule","year":2018,"lang":"en","type":"article","venue":"Cell Death Discovery","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Hrvatska Zaklada za Znanost; Government of Canada","keywords":"Vorinostat; Temozolomide; Cancer research; HDAC6; Glioma; Buthionine sulfoximine; Pharmacology; Acetylation; Chemistry; Mechanism of action; Biology; Histone deacetylase; Biochemistry; Glutathione; Histone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001789924,0.0001423636,0.0001986201,0.0001314348,0.00005055804,0.00001157216,0.00009324823,0.0001166374,0.000009167405],"category_scores_gemma":[0.0000581592,0.0001431987,0.00007657118,0.0001224525,0.0001964542,0.00002644344,0.0001291833,0.00007446631,0.000002518568],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002054619,"about_ca_system_score_gemma":0.0001567015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003578964,"about_ca_topic_score_gemma":0.00002884789,"domain_scores_codex":[0.9988618,0.00005377998,0.0003562774,0.0003129086,0.0002451611,0.0001700159],"domain_scores_gemma":[0.9991019,0.00001060015,0.0002416315,0.0003186077,0.0002702184,0.00005700662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002485759,0.0003063141,0.00009811454,0.000233875,0.00001312324,0.000001302343,0.0001070421,0.00001289366,0.9985575,0.000111749,0.0002518464,0.00005766146],"study_design_scores_gemma":[0.000900337,0.001187044,0.00006272104,0.00005698211,0.00001962213,0.00001239137,0.00007031586,0.0003736119,0.9970478,0.00009312826,0.00005315133,0.0001228924],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840915,0.0001869544,0.01447255,0.0000102022,0.00007095012,0.0002764297,0.00008700944,0.000004867971,0.0007995049],"genre_scores_gemma":[0.9987783,0.0001021042,0.0004524662,0.00002152758,0.00009426492,0.00001535777,0.00009066275,0.00002421387,0.0004210355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01468684,"threshold_uncertainty_score":0.5839472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01387966389674864,"score_gpt":0.2518165900318172,"score_spread":0.2379369261350685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}