{"id":"W2892758519","doi":"10.1038/s41591-018-0146-z","title":"Genetic mechanisms of target antigen loss in CAR19 therapy of acute lymphoblastic leukemia","year":2018,"lang":"en","type":"article","venue":"Nature Medicine","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":567,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"CD19; Chimeric antigen receptor; Loss of heterozygosity; Biology; Antigen; Cancer research; Mutation; Immunology; Gene; Genetics; T cell; Allele; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006145802,0.0002459981,0.0008534596,0.0005259822,0.00002656971,0.000002090845,0.0003007014,0.0004463572,0.003674824],"category_scores_gemma":[0.0001899909,0.0001731906,0.0001068853,0.0009445762,0.0006544208,0.00003169872,0.00005600836,0.0006236249,0.00001237435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002321512,"about_ca_system_score_gemma":0.0004822501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002912637,"about_ca_topic_score_gemma":0.0000356927,"domain_scores_codex":[0.9975026,0.00009474924,0.0005706943,0.0003727447,0.001037887,0.0004213037],"domain_scores_gemma":[0.9983683,0.0001581876,0.0001727156,0.0006367713,0.0004918511,0.0001722033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001739644,0.0001202676,0.01258963,0.000111327,0.0003007381,0.0001884194,0.001242759,0.000002813731,0.9760619,0.0003221895,0.0009989311,0.006321376],"study_design_scores_gemma":[0.011388,0.004931884,0.1315388,0.0006618403,0.00009167576,0.0002019963,0.0001821429,0.0005327331,0.8427359,0.002538651,0.004994619,0.0002017368],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900644,0.003905974,0.0008968255,0.0008631236,0.0004829726,0.0007064844,0.00001788655,0.00002814872,0.003034129],"genre_scores_gemma":[0.9937488,0.002015161,0.001754672,0.0007346844,0.0006394442,0.00001176984,0.00002581516,0.00005127351,0.001018328],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.133326,"threshold_uncertainty_score":0.997236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01147386622342116,"score_gpt":0.3115330090825917,"score_spread":0.3000591428591705,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}