{"id":"W2892819708","doi":"10.1016/j.cell.2018.08.070","title":"The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery","year":2018,"lang":"en","type":"article","venue":"Cell","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":253,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"National Key Research and Development Program of China; Beijing Municipal Science and Technology Commission; National Natural Science Foundation of China","keywords":"Biology; Druggability; Mevalonate pathway; Adjuvant; Vaccine adjuvant; Computational biology; Virology; Bioinformatics; Immunology; Genetics; Biosynthesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003968475,0.0005441067,0.0003859004,0.0003763599,0.0002367637,0.00116928,0.0002067347,0.0006932287,0.001578439],"category_scores_gemma":[0.0001673799,0.0001522119,0.0001967397,0.000197173,0.0005056766,0.001055911,0.0004734969,0.0009234481,0.000543996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005553804,"about_ca_system_score_gemma":0.0005555085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002112802,"about_ca_topic_score_gemma":0.0004369071,"domain_scores_codex":[0.9999025,0.00001922775,0.000005158375,0.00001707267,0.00002560918,0.00003044848],"domain_scores_gemma":[0.9999099,0.00001727382,0.00002437672,0.000009101915,0.00001625525,0.00002310276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006410782,0.00007608053,0.001111961,0.0004001714,0.00002581193,0.0002726284,0.00005642459,0.0007624635,0.9421089,0.01608324,0.001223743,0.03723752],"study_design_scores_gemma":[0.000141543,0.001802156,0.004392773,0.0002117106,0.00009076965,0.00144861,0.0004093623,0.002516629,0.8345077,0.02596681,0.1284756,0.00003646024],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.612673,0.3140613,0.04038224,0.01394421,0.001148082,0.0001687242,0.0008076569,0.0003590061,0.01645577],"genre_scores_gemma":[0.916515,0.06839215,0.006922547,0.0006058945,0.0001899699,0.00004394794,0.0002947517,0.00002385674,0.007011753],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001578439,"threshold_uncertainty_score":0.005280435,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007656399049608032,"score_gpt":0.2150987285823511,"score_spread":0.2074423295327431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}