{"id":"W2892819708","doi":"10.1016/j.cell.2018.08.070","title":"The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery","year":2018,"lang":"en","type":"article","venue":"Cell","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":253,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"National Key Research and Development Program of China; Beijing Municipal Science and Technology Commission; National Natural Science Foundation of China","keywords":"Biology; Druggability; Mevalonate pathway; Adjuvant; Vaccine adjuvant; Computational biology; Virology; Bioinformatics; Immunology; Genetics; Biosynthesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003143699,0.0001624637,0.000195135,0.00002852388,0.0006464705,0.00004820885,0.000334159,0.0001474532,0.0007825095],"category_scores_gemma":[0.00003217784,0.0001020417,0.0001278233,0.0000674496,0.00009721862,0.0001128912,0.0001052228,0.0001450335,0.001197494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002139196,"about_ca_system_score_gemma":0.00006168261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002781867,"about_ca_topic_score_gemma":0.00001747669,"domain_scores_codex":[0.998957,0.00005792985,0.0002232181,0.0002697115,0.00002668189,0.0004654021],"domain_scores_gemma":[0.999258,0.0001203144,0.00009781696,0.0004253143,0.00008209724,0.00001638637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002121567,0.0000699384,0.0000146305,0.0000106167,0.00005497452,6.834517e-7,0.00036715,2.595841e-7,0.9182547,0.001800107,0.07662489,0.00258993],"study_design_scores_gemma":[0.0007452376,0.0002922736,0.00004952972,0.00000551008,0.00001113965,0.000002860957,0.0001216178,0.00001050991,0.5167585,0.001824527,0.4800907,0.00008756253],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8606033,0.04942728,0.02467898,0.004549727,0.02134027,0.003483937,0.001346643,0.0004192881,0.03415057],"genre_scores_gemma":[0.8215505,0.0001960032,0.0005024353,0.0007329347,0.0001518141,0.00008579198,0.00007569171,0.0000340134,0.1766708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4034659,"threshold_uncertainty_score":0.9995802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007656399049608032,"score_gpt":0.2150987285823511,"score_spread":0.2074423295327431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}