{"id":"W2892935322","doi":"10.18632/oncotarget.26173","title":"Functional characterization of phospholipase C-γ2 mutant protein causing both somatic ibrutinib resistance and a germline monogenic autoinflammatory disorder","year":2018,"lang":"en","type":"article","venue":"Oncotarget","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"International Graduate School in Molecular Medicine Ulm; Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberg; Deutsche Forschungsgemeinschaft","keywords":"Bruton's tyrosine kinase; Chronic lymphocytic leukemia; Mutation; Mutant; Germline mutation; LYN; Cancer research; Immune system; Biology; Somatic cell; Signal transduction; Immunology; Tyrosine kinase; Leukemia; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003663038,0.0001923985,0.0003699239,0.0001254669,0.000132649,0.00002218657,0.00006226445,0.0001155525,0.0006272738],"category_scores_gemma":[0.0001984137,0.0001710734,0.00006899703,0.0002852685,0.0003348349,0.0001473456,0.0000827527,0.0001525805,0.00004294417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001516987,"about_ca_system_score_gemma":0.002853108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001129481,"about_ca_topic_score_gemma":0.0000663427,"domain_scores_codex":[0.9982013,0.00006088936,0.0004940494,0.0003611018,0.000522118,0.0003605244],"domain_scores_gemma":[0.9989412,0.00005030615,0.0002166726,0.0004100698,0.0002108661,0.0001708292],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001307965,0.0002348641,0.004324348,0.0008448305,0.0001159208,0.0001108045,0.0006933172,0.000002359958,0.9911173,0.0002955921,0.0003120491,0.0006406598],"study_design_scores_gemma":[0.04631395,0.001231338,0.2724864,0.002804761,0.0003399565,0.0006129561,0.0002410988,0.07176768,0.5629972,0.0008779869,0.03928238,0.001044278],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964069,0.0003940178,0.001296269,0.0004476706,0.0001087015,0.0008145553,0.00003130603,0.00006487348,0.0004356973],"genre_scores_gemma":[0.9938826,0.00004413024,0.001427201,0.0001076909,0.0003413477,0.00006365002,0.0001098567,0.00004594891,0.003977579],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.42812,"threshold_uncertainty_score":0.6976171,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0135994256504052,"score_gpt":0.2618322140456263,"score_spread":0.2482327883952211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}