{"id":"W2892946876","doi":"10.1002/mds.101","title":"Noninvasive delivery of an α‐synuclein gene silencing vector with magnetic resonance–guided focused ultrasound","year":2018,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; Sunnybrook Hospital; University of Toronto","funders":"National Institute of Biomedical Imaging and Bioengineering","keywords":"Gene silencing; Neuroscience; Olfactory bulb; Magnetic resonance imaging; Tyrosine hydroxylase; Synaptophysin; Gene delivery; Biology; Substantia nigra; Pathology; Medicine; Parkinson's disease; Central nervous system; Genetic enhancement; Gene; Immunohistochemistry; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005474233,0.0001760488,0.0001652309,0.00006738904,0.00009977412,0.00002471126,0.0001853179,0.00004969671,0.0002692053],"category_scores_gemma":[0.000007426415,0.000164792,0.0000418784,0.0002210453,0.0001260559,0.000119931,0.00001229293,0.00006880906,0.00002585688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000558612,"about_ca_system_score_gemma":0.00002859009,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002508615,"about_ca_topic_score_gemma":0.001174662,"domain_scores_codex":[0.999092,0.00001422312,0.0002168528,0.0002221327,0.0001878607,0.0002669483],"domain_scores_gemma":[0.9994221,0.00005422536,0.00003765598,0.0003515167,0.00006295361,0.00007159446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004513778,0.0002693303,0.005602744,0.00006765587,0.0001030996,0.000003536678,0.003249709,0.002571657,0.9618874,0.0006095272,0.00133125,0.02425894],"study_design_scores_gemma":[0.00520271,0.002850648,0.1166608,0.0002091211,0.0002602741,0.000006019501,0.003339992,0.01365694,0.8402389,0.007373075,0.008392844,0.001808671],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953372,0.0005524525,0.001156144,0.00004652132,0.0000620246,0.0003067492,0.00003466468,0.0001508592,0.002353335],"genre_scores_gemma":[0.9960733,0.0001808843,0.003207555,0.0002488575,0.00006855393,0.00007226676,0.00002036946,0.00005291019,0.0000752733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1216485,"threshold_uncertainty_score":0.6720024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006543941598901359,"score_gpt":0.1902681324995843,"score_spread":0.1837241909006829,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}