{"id":"W2892946876","doi":"10.1002/mds.101","title":"Noninvasive delivery of an α‐synuclein gene silencing vector with magnetic resonance–guided focused ultrasound","year":2018,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; Sunnybrook Hospital; University of Toronto","funders":"National Institute of Biomedical Imaging and Bioengineering","keywords":"Gene silencing; Neuroscience; Olfactory bulb; Magnetic resonance imaging; Tyrosine hydroxylase; Synaptophysin; Gene delivery; Biology; Substantia nigra; Pathology; Medicine; Parkinson's disease; Central nervous system; Genetic enhancement; Gene; Immunohistochemistry; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002883372,0.0005696285,0.0002498695,0.0001950687,0.0001032899,0.0002970644,0.0002662079,0.0005353699,0.0005246884],"category_scores_gemma":[0.0002135102,0.0002117139,0.0002696498,0.00007981324,0.0004434861,0.0002911896,0.0002317105,0.0004033252,0.0001853019],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002914804,"about_ca_system_score_gemma":0.0002181659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006196349,"about_ca_topic_score_gemma":0.0006725185,"domain_scores_codex":[0.9998255,0.00002614531,0.00001281352,0.00004584463,0.00006272257,0.00002691843],"domain_scores_gemma":[0.9998672,0.00003590713,0.00005242964,0.00001201203,0.00001422884,0.00001826068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001917152,0.00001254928,0.0000306711,0.00001441591,0.000001914121,0.00001547222,0.000006745571,0.00004471885,0.9993712,0.00002516515,0.00001175691,0.0004462272],"study_design_scores_gemma":[0.00001834701,0.0004117938,0.0006588147,0.000004661486,0.00001605487,0.00009385687,0.000006968797,0.001169999,0.9969684,0.00002122374,0.0006247975,0.00000509711],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9544563,0.001684837,0.04192569,0.0002493922,0.00005295838,0.000178461,0.00006898951,0.0003308963,0.001052457],"genre_scores_gemma":[0.9678442,0.001325098,0.02776786,0.0001410944,0.00003577088,0.0002118183,0.0001364756,0.00004805755,0.002489608],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006196349,"threshold_uncertainty_score":0.002114832,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006543941598901359,"score_gpt":0.1902681324995843,"score_spread":0.1837241909006829,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}