{"id":"W2893086430","doi":"10.1002/hep4.1244","title":"Placebo‐Controlled Randomized Trial of an Intestinal Bile Salt Transport Inhibitor for Pruritus in Alagille Syndrome","year":2018,"lang":"en","type":"article","venue":"Hepatology Communications","topic":"Pediatric Hepatobiliary Diseases and Treatments","field":"Medicine","cited_by":101,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Center for Advancing Translational Sciences; Audentes Therapeutics; National Institutes of Health; Cincinnati Children's Hospital Medical Center; Children's Hospital of Philadelphia; Alexion Pharmaceuticals; National Institute of Diabetes and Digestive and Kidney Diseases; Children's Healthcare of Atlanta; Gilead Sciences; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Placebo; Medicine; Alagille syndrome; Gastroenterology; Internal medicine; Enterohepatic circulation; Clinical endpoint; Confidence interval; Cholestasis; Randomized controlled trial; Surgery; Bile acid; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002839162,0.001884604,0.004753618,0.0005031814,0.0006743952,0.001407655,0.001096255,0.002776347,0.01032914],"category_scores_gemma":[0.004172191,0.0009287188,0.002198742,0.0004314032,0.00147449,0.00114737,0.0005560399,0.003903902,0.001358904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008691492,"about_ca_system_score_gemma":0.001232011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001263733,"about_ca_topic_score_gemma":0.002244379,"domain_scores_codex":[0.998184,0.001122892,0.000131863,0.0002687573,0.0001082425,0.0001841637],"domain_scores_gemma":[0.9982602,0.0006480411,0.0003746531,0.0001346471,0.0001557029,0.0004268562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9930235,0.002074308,0.0001097072,0.0003841237,0.0006609466,0.00001245176,0.00001392118,0.00008610012,0.0006647514,0.00005383473,0.0002791291,0.002637184],"study_design_scores_gemma":[0.9769233,0.0219412,0.0003969979,0.00002112072,0.0002334554,0.000006827444,0.000008501553,0.0001273747,0.00009304981,0.00006245657,0.0001800933,0.000005564633],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9643685,0.009533676,0.001551895,0.001758109,0.003020888,0.01334614,0.002239769,0.0003157528,0.003865344],"genre_scores_gemma":[0.9777999,0.002292051,0.002031193,0.001599544,0.000809412,0.01116316,0.0009815542,0.00002942519,0.003293743],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01032914,"threshold_uncertainty_score":0.03455436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02561559524855327,"score_gpt":0.3291301450572456,"score_spread":0.3035145498086923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}