{"id":"W2893109079","doi":"10.1002/jcph.1113","title":"Opioids in Breast Milk: Pharmacokinetic Principles and Clinical Implications","year":2018,"lang":"en","type":"review","venue":"The Journal of Clinical Pharmacology","topic":"Prenatal Substance Exposure Effects","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Medicine; Oxycodone; Methadone; Breastfeeding; Opioid; Pharmacokinetics; Buprenorphine; Tramadol; Breast milk; Adverse effect; Drug; CYP2D6; Pharmacology; Anesthesia; Pediatrics; Internal medicine; Analgesic","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00179212,0.0006701276,0.001249866,0.0007705325,0.0003569305,0.002342896,0.001174174,0.002154387,0.00151984],"category_scores_gemma":[0.00395901,0.0004430902,0.0005658988,0.0006487769,0.001618126,0.001868193,0.0007590023,0.002637786,0.0006901931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001198988,"about_ca_system_score_gemma":0.001165771,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009709437,"about_ca_topic_score_gemma":0.0008182069,"domain_scores_codex":[0.9992728,0.0002674416,0.00006363932,0.00009158069,0.0002604967,0.00004411914],"domain_scores_gemma":[0.9983764,0.0008452201,0.0003353408,0.0000712789,0.0002688337,0.0001028758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002141563,0.0008564434,0.03085638,0.005380865,0.0002515176,0.01311919,0.001083008,0.005796848,0.01876254,0.06957009,0.0185018,0.8336798],"study_design_scores_gemma":[0.0005738102,0.006253933,0.08908938,0.006731205,0.000748643,0.09320075,0.002479268,0.02995309,0.02463007,0.236095,0.5097857,0.0004591064],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02768283,0.9061673,0.01322447,0.04104432,0.0006297453,0.0000704737,0.0001738423,0.0001177322,0.0108893],"genre_scores_gemma":[0.3025559,0.6659161,0.01321817,0.009759981,0.003960684,0.0002615205,0.0001357458,0.00006159192,0.004130314],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002342896,"threshold_uncertainty_score":0.009477735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1717185619706048,"score_gpt":0.5239676029081161,"score_spread":0.3522490409375112,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}