{"id":"W2893129486","doi":"10.1038/s41467-018-06183-4","title":"Bi-directional cell-pericellular matrix interactions direct stem cell fate","year":2018,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":131,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"London Centre for Nanotechnology; Medical Research Council; AO Foundation; Imperial College London; Wellcome Trust; Francis Crick Institute; NIHR Imperial Biomedical Research Centre; Cancer Research UK; Leverhulme Trust; Rosetrees Trust; Whitaker International Program","keywords":"Self-healing hydrogels; Cell biology; Adipogenesis; Stromal cell; Cell fate determination; Matrix (chemical analysis); Extracellular matrix; Mesenchymal stem cell; Stem cell; Cell; Chemistry; Niche; Spheroid; Biophysics; Biology; Biochemistry; In vitro; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000169611,0.0002022794,0.0001443544,0.000125377,0.0006574126,0.00007476291,0.000824951,0.0002871959,0.0002131962],"category_scores_gemma":[0.00002917594,0.0002092466,0.0001903214,0.0003098716,0.0001197332,0.00001668764,0.0004571447,0.0006665289,0.0002657775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005188957,"about_ca_system_score_gemma":0.00009105691,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003224694,"about_ca_topic_score_gemma":0.0003341692,"domain_scores_codex":[0.9988128,0.0001477048,0.0002811492,0.0003668987,0.0001490013,0.0002424689],"domain_scores_gemma":[0.9974955,0.00006031003,0.0001551183,0.001795055,0.0003850106,0.0001089494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002384045,0.0002968569,0.0001186984,0.000006322716,0.00005187704,6.144738e-7,0.00007933665,0.000008667789,0.9655818,0.0008303056,0.03247908,0.0005225873],"study_design_scores_gemma":[0.000152335,0.00008658348,0.00008144556,0.000007637294,0.00003160748,0.00001450272,0.0001261337,0.0007331926,0.3503426,0.00002328715,0.6482304,0.000170262],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"other","genre_gemma":"empirical","genre_scores_codex":[0.3561932,0.04453694,0.01510069,0.004891417,0.008119734,0.001458927,0.0005967753,0.0004673983,0.5686349],"genre_scores_gemma":[0.9752985,0.001090472,0.004011727,0.0003416926,0.0004513734,0.00006771187,0.0005397903,0.00004312218,0.01815566],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.6191052,"threshold_uncertainty_score":0.853283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01248870874247354,"score_gpt":0.2921093382186081,"score_spread":0.2796206294761345,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}