{"id":"W2893129486","doi":"10.1038/s41467-018-06183-4","title":"Bi-directional cell-pericellular matrix interactions direct stem cell fate","year":2018,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":131,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"London Centre for Nanotechnology; Medical Research Council; AO Foundation; Imperial College London; Wellcome Trust; Francis Crick Institute; NIHR Imperial Biomedical Research Centre; Cancer Research UK; Leverhulme Trust; Rosetrees Trust; Whitaker International Program","keywords":"Self-healing hydrogels; Cell biology; Adipogenesis; Stromal cell; Cell fate determination; Matrix (chemical analysis); Extracellular matrix; Mesenchymal stem cell; Stem cell; Cell; Chemistry; Niche; Spheroid; Biophysics; Biology; Biochemistry; In vitro; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001144863,0.0002146545,0.0000901639,0.0001363558,0.0001557132,0.0004130676,0.00009303276,0.0001476291,0.001092064],"category_scores_gemma":[0.0001384783,0.0001183019,0.00007799023,0.0001403149,0.0002255197,0.0002145794,0.000309356,0.0002008446,0.0003190436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001272686,"about_ca_system_score_gemma":0.0002236485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003750026,"about_ca_topic_score_gemma":0.001312216,"domain_scores_codex":[0.9998766,0.00001942713,0.000008200928,0.00002425694,0.00004687734,0.00002457956],"domain_scores_gemma":[0.9998878,0.00003468667,0.0000287661,0.00001380253,0.00001147457,0.00002351455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001486725,0.000003755855,0.0003656174,0.00001540482,0.000001723361,0.0000311665,0.00001715912,0.00007171882,0.99743,0.0001807615,0.00002702154,0.001840914],"study_design_scores_gemma":[0.000003918236,0.00004400087,0.00261817,0.00000317264,0.000004866363,0.00009761292,0.00004720415,0.00105636,0.9943136,0.0000873027,0.001721198,0.000002563391],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992314,0.001195069,0.004027736,0.00007688891,0.00001699507,0.000009329499,0.00009787852,0.00004644016,0.002215603],"genre_scores_gemma":[0.995837,0.0005287742,0.002118815,0.00001899051,0.000006358296,0.000008912133,0.00004996696,0.00001117186,0.001420087],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001092064,"threshold_uncertainty_score":0.003653347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01248870874247354,"score_gpt":0.2921093382186081,"score_spread":0.2796206294761345,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}