{"id":"W2893158201","doi":"10.1038/s41598-018-33096-5","title":"Calcineurin B homologous protein 3 binds with high affinity to the CHP binding domain of the human sodium/proton exchanger NHE1","year":2018,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; Deutsche Forschungsgemeinschaft","keywords":"Microscale thermophoresis; Chemistry; Calcineurin; Isothermal titration calorimetry; Sodium–hydrogen antiporter; Dissociation constant; Biophysics; Binding site; Biochemistry; Sodium; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008311663,0.0001299441,0.0001128534,0.00006228346,0.0005164856,0.00004945696,0.0002294965,0.0000891312,0.00003961219],"category_scores_gemma":[0.00002109536,0.00007029307,0.00007123919,0.0003674462,0.0004372637,0.000005256183,0.00008787059,0.00006970933,0.000005299858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001589698,"about_ca_system_score_gemma":0.00008285324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006387107,"about_ca_topic_score_gemma":0.000269266,"domain_scores_codex":[0.9986235,0.00005220989,0.000272976,0.0004789318,0.000333485,0.0002389351],"domain_scores_gemma":[0.9986094,0.000002031545,0.000232458,0.0009034188,0.0001968844,0.00005585462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003366801,0.00004526901,0.003538623,0.00002007726,0.0000152425,0.00001404313,0.0002843212,0.00001536898,0.994697,0.00005367702,0.001122714,0.0001599761],"study_design_scores_gemma":[0.0001269725,0.0002333499,0.007533003,0.00003276603,0.00001229042,0.00003779687,0.00005897193,0.000001363115,0.9631613,0.0003558871,0.0283371,0.0001091765],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967983,0.00002369047,0.0001590972,0.0003608584,0.001333705,0.001029887,0.000005780148,0.00001141972,0.0002772575],"genre_scores_gemma":[0.9956287,3.097026e-7,0.000114208,0.00003307499,0.0003104568,0.0001181146,0.00006713103,0.00001515311,0.003712809],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0315357,"threshold_uncertainty_score":0.3972442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01039048707261189,"score_gpt":0.2315201077089682,"score_spread":0.2211296206363563,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}