{"id":"W2893177211","doi":"10.1038/s41398-018-0229-0","title":"Genetic risk for schizophrenia and autism, social impairment and developmental pathways to psychosis","year":2018,"lang":"en","type":"article","venue":"Translational Psychiatry","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Baycrest Hospital; University of Toronto","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institutes of Health; Vetenskapsrådet; National Institute of Mental Health; Svenska Forskningsrådet Formas; Fondation pour la Recherche Médicale; Lundbeckfonden; EU Joint Programme – Neurodegenerative Disease Research; Institut National de la Santé et de la Recherche Médicale; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Agence Nationale de la Recherche; Medical Research Council; Universität Heidelberg; University of Toronto; Deutsche Forschungsgemeinschaft; University College Dublin; Mission Interministérielle de Lutte Contre les Drogues et les Conduites Addictives; South London and Maudsley NHS Foundation Trust; Universität Hamburg; Science Foundation Ireland; King's College London; Fondation de France; Technische Universität Dresden; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research","keywords":"Autism; Psychosis; Schizophrenia (object-oriented programming); Psychology; Autism spectrum disorder; Polygenic risk score; Population; Psychiatry; Clinical psychology; Structural equation modeling; Developmental psychology; Medicine; Single-nucleotide polymorphism; Genetics; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003865897,0.0002673811,0.0001570608,0.0008104889,0.0003383421,0.0004204814,0.0001511231,0.000233189,0.001982509],"category_scores_gemma":[0.001243669,0.0001584663,0.0002637164,0.0006827879,0.0002726923,0.0001626467,0.0004819275,0.000294359,0.0001165451],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003721602,"about_ca_system_score_gemma":0.0005051541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01101824,"about_ca_topic_score_gemma":0.01133816,"domain_scores_codex":[0.9998074,0.00006094924,0.00001910179,0.00005212718,0.00003348494,0.00002698464],"domain_scores_gemma":[0.9995155,0.00006743384,0.0002917898,0.00003230263,0.00002864446,0.00006434698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001381548,0.00003237023,0.9938874,0.00001551222,0.00008021624,0.0002132834,0.00009680069,0.000138745,0.001265296,0.0002297904,0.00004900421,0.003853511],"study_design_scores_gemma":[0.000004526617,0.00004328278,0.9987103,0.000009668753,0.00003268135,0.0003336318,0.00005789342,0.0003209078,0.0001141444,0.0002772282,0.00009307812,0.000002668446],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987987,0.0003373344,0.0001749596,0.00006344785,0.000001717161,0.000006284627,0.0001867714,0.00000515157,0.0004256227],"genre_scores_gemma":[0.999245,0.0002177225,0.0002731272,0.000006462099,0.000002128151,0.000005173028,0.0001042639,0.000001114185,0.0001450146],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01101824,"threshold_uncertainty_score":0.02190822,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01333057890543021,"score_gpt":0.2648434303669244,"score_spread":0.2515128514614942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}