{"id":"W2893177211","doi":"10.1038/s41398-018-0229-0","title":"Genetic risk for schizophrenia and autism, social impairment and developmental pathways to psychosis","year":2018,"lang":"en","type":"article","venue":"Translational Psychiatry","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Baycrest Hospital; University of Toronto","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institutes of Health; Vetenskapsrådet; National Institute of Mental Health; Svenska Forskningsrådet Formas; Fondation pour la Recherche Médicale; Lundbeckfonden; EU Joint Programme – Neurodegenerative Disease Research; Institut National de la Santé et de la Recherche Médicale; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Agence Nationale de la Recherche; Medical Research Council; Universität Heidelberg; University of Toronto; Deutsche Forschungsgemeinschaft; University College Dublin; Mission Interministérielle de Lutte Contre les Drogues et les Conduites Addictives; South London and Maudsley NHS Foundation Trust; Universität Hamburg; Science Foundation Ireland; King's College London; Fondation de France; Technische Universität Dresden; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research","keywords":"Autism; Psychosis; Schizophrenia (object-oriented programming); Psychology; Autism spectrum disorder; Polygenic risk score; Population; Psychiatry; Clinical psychology; Structural equation modeling; Developmental psychology; Medicine; Single-nucleotide polymorphism; Genetics; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000137157,0.0001149327,0.0001049381,0.00003920509,0.000243028,0.00001117608,0.00005220911,0.0001169251,0.00003744679],"category_scores_gemma":[0.00001440376,0.0001172054,0.00004260386,0.00004724506,0.00007183657,0.00000176873,0.00001823028,0.0000341043,0.00001154373],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000516992,"about_ca_system_score_gemma":0.00006048415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009311183,"about_ca_topic_score_gemma":0.0001878089,"domain_scores_codex":[0.9992412,0.00003348905,0.000186641,0.0003011012,0.0000592047,0.0001783151],"domain_scores_gemma":[0.9997616,0.00001430851,0.000052887,0.00006103707,0.00002791558,0.00008225436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005271245,0.0001443821,0.9155434,0.00002930024,0.0002663585,9.64443e-8,0.0007621924,0.00001876455,0.01015695,0.0041361,0.03241659,0.03599879],"study_design_scores_gemma":[0.001047686,0.0003126591,0.9796752,0.000004087847,0.00002706818,0.000006148109,0.0000573543,0.000108928,0.00005499694,0.006027698,0.01251786,0.0001602556],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.97684,0.0003546372,0.01945391,0.002170174,0.0001773672,0.0002990451,0.0001235021,0.00001093342,0.0005704812],"genre_scores_gemma":[0.8278427,0.00003888215,0.1711027,0.0004273184,0.0003873912,0.00004768246,0.00003341516,0.00001958971,0.0001004108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1516487,"threshold_uncertainty_score":0.4779496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01333057890543021,"score_gpt":0.2648434303669244,"score_spread":0.2515128514614942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}