{"id":"W2893350786","doi":"10.1038/s41426-018-0165-3","title":"Small molecules targeting coxsackievirus A16 capsid inactivate viral particles and prevent viral binding","year":2018,"lang":"en","type":"article","venue":"Emerging Microbes & Infections","topic":"Viral Infections and Immunology Research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Izaak Walton Killam Health Centre; Dalhousie University","funders":"Kaohsiung Medical University; Ministry of Science and Technology, Taiwan; University of Texas at Austin","keywords":"Capsid; Coxsackievirus; Virology; Infectivity; Docking (animal); Cytotoxicity; Biology; Chemistry; Virus; Medicine; Enterovirus; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009187711,0.0002441834,0.0001909142,0.0001446527,0.00009040341,0.000153144,0.0001418329,0.0002189837,0.0008877178],"category_scores_gemma":[0.00007938687,0.00008004799,0.000221455,0.00007054906,0.0001809196,0.0001455076,0.0001697854,0.0003659512,0.0001784228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001490537,"about_ca_system_score_gemma":0.000130082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004389849,"about_ca_topic_score_gemma":0.0009749449,"domain_scores_codex":[0.9999576,0.000008242067,0.000002248512,0.000008154237,0.000008819758,0.0000149473],"domain_scores_gemma":[0.9999725,0.000007537421,0.000007116368,0.000003124376,0.000003956026,0.000005822968],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001379799,0.0000573143,0.0001521652,0.0001294936,0.00001638909,0.00004609679,0.00001645804,0.0003676222,0.9928311,0.0002299472,0.00007840259,0.00593707],"study_design_scores_gemma":[0.00007301508,0.001560444,0.001769155,0.00001787209,0.00002116524,0.0001479807,0.00002715929,0.001359431,0.9888707,0.0001076361,0.00603861,0.000006836141],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854141,0.007119432,0.004741377,0.0001440557,0.00005346685,0.0001028612,0.0001698514,0.00006365867,0.002191227],"genre_scores_gemma":[0.9908955,0.00331988,0.003428287,0.0001096604,0.000007813515,0.00004233379,0.0001482067,0.000006830959,0.002041584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008877178,"threshold_uncertainty_score":0.002969742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0230832073444501,"score_gpt":0.3015424103335663,"score_spread":0.2784592029891163,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}