{"id":"W2893350786","doi":"10.1038/s41426-018-0165-3","title":"Small molecules targeting coxsackievirus A16 capsid inactivate viral particles and prevent viral binding","year":2018,"lang":"en","type":"article","venue":"Emerging Microbes & Infections","topic":"Viral Infections and Immunology Research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Izaak Walton Killam Health Centre; Dalhousie University","funders":"Kaohsiung Medical University; Ministry of Science and Technology, Taiwan; University of Texas at Austin","keywords":"Capsid; Coxsackievirus; Virology; Infectivity; Docking (animal); Cytotoxicity; Biology; Chemistry; Virus; Medicine; Enterovirus; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003382674,0.0002301681,0.0002862813,0.0003593167,0.0009959935,0.00008520458,0.00007413698,0.0001293355,0.0002203627],"category_scores_gemma":[0.0002048805,0.0002138833,0.000122581,0.0004037702,0.0004506377,0.0002237359,0.0001776512,0.0004747372,0.0001988021],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001243352,"about_ca_system_score_gemma":0.00007890243,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007133561,"about_ca_topic_score_gemma":0.0001226167,"domain_scores_codex":[0.9984455,0.0001375489,0.0003505357,0.0003882913,0.0001065209,0.0005716375],"domain_scores_gemma":[0.9992702,0.00005933308,0.00009608461,0.0002569082,0.0001837621,0.0001336814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000054206,0.0003605682,0.02676162,0.00004514646,0.0002197082,0.00001138948,0.0005058838,0.00001437095,0.9637607,0.0006110918,0.001064796,0.006590538],"study_design_scores_gemma":[0.002077393,0.002447768,0.02045411,0.0003823247,0.0002937023,0.0004700891,0.0008243383,0.001322558,0.90796,0.0005693368,0.06256127,0.0006370883],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940758,0.0008460829,0.001517026,0.0008458122,0.0003953061,0.0003577853,0.00001021911,0.0002026517,0.001749296],"genre_scores_gemma":[0.9964775,0.000469667,0.001331323,0.0001516052,0.0003080606,0.00005746438,0.000023353,0.0000427776,0.001138245],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06149647,"threshold_uncertainty_score":0.8721908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0230832073444501,"score_gpt":0.3015424103335663,"score_spread":0.2784592029891163,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}