{"id":"W2893379478","doi":"10.18433/jpps30010","title":"Design and Evaluation of Gemini Surfactant-Based Lipoplexes Modified with Cell-Binding Peptide for Targeted Gene Therapy in Melanoma Model","year":2018,"lang":"en","type":"article","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Saskatchewan","funders":"Taibah University","keywords":"Gene delivery; Peptide; Zeta potential; Chemistry; Transfection; Genetic enhancement; Biophysics; Pulmonary surfactant; In vitro; Cell biology; Cancer research; Biochemistry; Biology; Gene; Nanotechnology; Materials science; Nanoparticle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003073631,0.0003603699,0.0002004266,0.0001871146,0.000120018,0.0002330134,0.000174544,0.0003354248,0.0002423465],"category_scores_gemma":[0.0002104737,0.000119066,0.0001942046,0.0001185925,0.000165966,0.0002644433,0.0001500374,0.0002628238,0.0001552453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003079068,"about_ca_system_score_gemma":0.0002319149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003343461,"about_ca_topic_score_gemma":0.0003518478,"domain_scores_codex":[0.9998997,0.00002219351,0.00001292668,0.00002287653,0.00003076096,0.0000115711],"domain_scores_gemma":[0.9999174,0.00001105699,0.00002761928,0.000004400509,0.00002335333,0.00001615085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004134207,0.00001863433,0.0001031855,0.00003164126,0.000003300612,0.00002598805,0.000009954332,0.0002119194,0.9986069,0.00004321084,0.000007584225,0.0008963596],"study_design_scores_gemma":[0.00001617029,0.0004163701,0.0006095553,0.000003573369,0.00001368697,0.00008456713,0.00000786377,0.001199348,0.9966336,0.00001592127,0.0009962913,0.000003113391],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877423,0.001647011,0.009659383,0.00005732215,0.00001660022,0.0002023467,0.00009081768,0.00004791793,0.0005362683],"genre_scores_gemma":[0.9737221,0.001806821,0.02253535,0.00005314415,0.000009688361,0.000197446,0.0002115246,0.00002155743,0.001442522],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003603699,"threshold_uncertainty_score":0.002233982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.129099689363435,"score_gpt":0.3941705772380125,"score_spread":0.2650708878745774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}