{"id":"W2893391390","doi":"10.1016/j.scr.2018.09.011","title":"Generation of integration-free iPS cell lines from three sickle cell disease patients from the state of Bahia, Brazil","year":2018,"lang":"en","type":"article","venue":"Stem Cell Research","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fundação de Amparo à Pesquisa do Estado da Bahia; Instituto Nacional de Ciência e Tecnologia em Medicina Regenerativa; Ministry of Health, British Columbia; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Biology; Induced pluripotent stem cell; Reprogramming; Disease; Peripheral blood mononuclear cell; Karyotype; Germ layer; Cell; Cell culture; Immunology; Cancer research; Embryonic stem cell; Gene; Genetics; Internal medicine; Chromosome; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003939357,0.000193138,0.000261441,0.0003644089,0.0004895239,0.0005386365,0.0002062448,0.0002769466,0.001010066],"category_scores_gemma":[0.0005653832,0.0001043185,0.0003192422,0.000226246,0.0002305159,0.00009906275,0.0004576696,0.0003731149,0.0002484122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002965378,"about_ca_system_score_gemma":0.0004376055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005347444,"about_ca_topic_score_gemma":0.007517455,"domain_scores_codex":[0.999843,0.00002102443,0.00003556695,0.00002714475,0.00004400561,0.0000293197],"domain_scores_gemma":[0.9998611,0.00002352678,0.0000181188,0.00002160063,0.0000533544,0.00002223739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000447989,0.0002922269,0.07567954,0.0002883204,0.00009895601,0.0127235,0.005007738,0.0007547957,0.8490555,0.002535585,0.001292461,0.05182336],"study_design_scores_gemma":[0.0005153324,0.002397633,0.2635239,0.0003718632,0.0009019465,0.08205384,0.007410604,0.005592769,0.5636774,0.00227249,0.07112314,0.0001590296],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875448,0.0009020091,0.006182414,0.00026754,0.00003618865,0.0002811059,0.001191645,0.00004284675,0.003551565],"genre_scores_gemma":[0.9914467,0.0007635255,0.004620715,0.0001926324,0.000006264897,0.0001347978,0.001685672,0.00001610618,0.001133575],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005347444,"threshold_uncertainty_score":0.01063263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03433696750502609,"score_gpt":0.3316566532569314,"score_spread":0.2973196857519053,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}